Zinc in PDB 7q59: Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
Enzymatic activity of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
All present enzymatic activity of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb:
2.7.7.6;
Other elements in 7q59:
The structure of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
(pdb code 7q59). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the
Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb, PDB code: 7q59:
Jump to Zinc binding site number:
1;
2;
3;
4;
Zinc binding site 1 out
of 4 in 7q59
Go back to
Zinc Binding Sites List in 7q59
Zinc binding site 1 out
of 4 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn1501
b:67.3
occ:1.00
|
SG
|
D:CYS891
|
2.3
|
41.5
|
1.0
|
SG
|
D:CYS978
|
2.3
|
42.3
|
1.0
|
SG
|
D:CYS968
|
2.3
|
46.7
|
1.0
|
SG
|
D:CYS975
|
2.3
|
39.5
|
1.0
|
CB
|
D:CYS978
|
3.2
|
42.3
|
1.0
|
CB
|
D:CYS891
|
3.2
|
41.5
|
1.0
|
CB
|
D:CYS968
|
3.3
|
46.7
|
1.0
|
CA
|
D:CYS968
|
3.4
|
46.7
|
1.0
|
CB
|
D:CYS975
|
3.4
|
39.5
|
1.0
|
N
|
D:ALA969
|
3.8
|
45.1
|
1.0
|
NH1
|
D:ARG963
|
3.9
|
45.1
|
1.0
|
N
|
D:CYS975
|
3.9
|
39.5
|
1.0
|
OG1
|
D:THR970
|
4.0
|
44.2
|
1.0
|
C
|
D:CYS968
|
4.1
|
46.7
|
1.0
|
N
|
D:CYS891
|
4.1
|
41.5
|
1.0
|
CA
|
D:CYS975
|
4.1
|
39.5
|
1.0
|
CA
|
D:CYS891
|
4.3
|
41.5
|
1.0
|
CA
|
D:CYS978
|
4.3
|
42.3
|
1.0
|
N
|
D:CYS978
|
4.4
|
42.3
|
1.0
|
O
|
D:CYS975
|
4.5
|
39.5
|
1.0
|
N
|
D:CYS968
|
4.6
|
46.7
|
1.0
|
CG2
|
D:THR893
|
4.6
|
46.8
|
1.0
|
C
|
D:CYS975
|
4.7
|
39.5
|
1.0
|
N
|
D:THR970
|
4.7
|
44.2
|
1.0
|
CA
|
D:ALA969
|
5.0
|
45.1
|
1.0
|
|
Zinc binding site 2 out
of 4 in 7q59
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Zinc Binding Sites List in 7q59
Zinc binding site 2 out
of 4 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn1502
b:139.8
occ:1.00
|
SG
|
D:CYS60
|
2.2
|
112.4
|
1.0
|
SG
|
D:CYS75
|
2.2
|
114.7
|
1.0
|
SG
|
D:CYS78
|
2.2
|
112.8
|
1.0
|
SG
|
D:CYS62
|
2.2
|
113.6
|
1.0
|
CB
|
D:CYS75
|
3.0
|
114.7
|
1.0
|
CB
|
D:CYS60
|
3.0
|
112.4
|
1.0
|
CB
|
D:CYS78
|
3.4
|
112.8
|
1.0
|
N
|
D:CYS62
|
3.5
|
113.6
|
1.0
|
CB
|
D:CYS62
|
3.6
|
113.6
|
1.0
|
N
|
D:CYS78
|
3.9
|
112.8
|
1.0
|
CB
|
D:LYS64
|
4.0
|
115.7
|
1.0
|
N
|
D:TYR61
|
4.0
|
107.6
|
1.0
|
CA
|
D:CYS62
|
4.0
|
113.6
|
1.0
|
CA
|
D:CYS60
|
4.2
|
112.4
|
1.0
|
N
|
D:LYS64
|
4.2
|
115.7
|
1.0
|
CA
|
D:CYS78
|
4.2
|
112.8
|
1.0
|
C
|
D:CYS60
|
4.3
|
112.4
|
1.0
|
N
|
D:GLY63
|
4.4
|
114.8
|
1.0
|
CA
|
D:CYS75
|
4.5
|
114.7
|
1.0
|
C
|
D:CYS62
|
4.5
|
113.6
|
1.0
|
CB
|
D:ARG77
|
4.5
|
113.7
|
1.0
|
CD1
|
D:TYR65
|
4.6
|
116.5
|
1.0
|
C
|
D:TYR61
|
4.6
|
107.6
|
1.0
|
CA
|
D:LYS64
|
4.7
|
115.7
|
1.0
|
CG2
|
D:VAL80
|
4.7
|
102.7
|
1.0
|
N
|
D:TYR65
|
4.8
|
116.5
|
1.0
|
C
|
D:ARG77
|
4.8
|
113.7
|
1.0
|
CA
|
D:TYR61
|
4.8
|
107.6
|
1.0
|
C
|
D:CYS75
|
4.9
|
114.7
|
1.0
|
|
Zinc binding site 3 out
of 4 in 7q59
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Zinc Binding Sites List in 7q59
Zinc binding site 3 out
of 4 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
d:Zn1501
b:67.3
occ:1.00
|
SG
|
d:CYS891
|
2.3
|
41.5
|
1.0
|
SG
|
d:CYS978
|
2.3
|
42.3
|
1.0
|
SG
|
d:CYS968
|
2.3
|
46.7
|
1.0
|
SG
|
d:CYS975
|
2.3
|
39.5
|
1.0
|
CB
|
d:CYS978
|
3.2
|
42.3
|
1.0
|
CB
|
d:CYS891
|
3.2
|
41.5
|
1.0
|
CB
|
d:CYS968
|
3.3
|
46.7
|
1.0
|
CA
|
d:CYS968
|
3.4
|
46.7
|
1.0
|
CB
|
d:CYS975
|
3.4
|
39.5
|
1.0
|
N
|
d:ALA969
|
3.8
|
45.1
|
1.0
|
NH1
|
d:ARG963
|
3.9
|
45.1
|
1.0
|
N
|
d:CYS975
|
3.9
|
39.5
|
1.0
|
OG1
|
d:THR970
|
4.0
|
44.2
|
1.0
|
C
|
d:CYS968
|
4.1
|
46.7
|
1.0
|
N
|
d:CYS891
|
4.1
|
41.5
|
1.0
|
CA
|
d:CYS975
|
4.1
|
39.5
|
1.0
|
CA
|
d:CYS891
|
4.3
|
41.5
|
1.0
|
CA
|
d:CYS978
|
4.3
|
42.3
|
1.0
|
N
|
d:CYS978
|
4.4
|
42.3
|
1.0
|
O
|
d:CYS975
|
4.5
|
39.5
|
1.0
|
N
|
d:CYS968
|
4.6
|
46.7
|
1.0
|
CG2
|
d:THR893
|
4.6
|
46.8
|
1.0
|
C
|
d:CYS975
|
4.7
|
39.5
|
1.0
|
N
|
d:THR970
|
4.7
|
44.2
|
1.0
|
CA
|
d:ALA969
|
5.0
|
45.1
|
1.0
|
|
Zinc binding site 4 out
of 4 in 7q59
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Zinc Binding Sites List in 7q59
Zinc binding site 4 out
of 4 in the Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Cryo-Em Structure of Mycobacterium Tuberculosis Rna Polymerase Holoenzyme Dimer Comprising Sigma Factor Sigb within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
d:Zn1502
b:139.8
occ:1.00
|
SG
|
d:CYS60
|
2.2
|
112.4
|
1.0
|
SG
|
d:CYS75
|
2.2
|
114.7
|
1.0
|
SG
|
d:CYS78
|
2.2
|
112.8
|
1.0
|
SG
|
d:CYS62
|
2.2
|
113.6
|
1.0
|
CB
|
d:CYS75
|
3.0
|
114.7
|
1.0
|
CB
|
d:CYS60
|
3.0
|
112.4
|
1.0
|
CB
|
d:CYS78
|
3.4
|
112.8
|
1.0
|
N
|
d:CYS62
|
3.5
|
113.6
|
1.0
|
CB
|
d:CYS62
|
3.6
|
113.6
|
1.0
|
N
|
d:CYS78
|
3.9
|
112.8
|
1.0
|
CB
|
d:LYS64
|
3.9
|
115.7
|
1.0
|
N
|
d:TYR61
|
4.0
|
107.6
|
1.0
|
CA
|
d:CYS62
|
4.0
|
113.6
|
1.0
|
CA
|
d:CYS60
|
4.2
|
112.4
|
1.0
|
N
|
d:LYS64
|
4.2
|
115.7
|
1.0
|
CA
|
d:CYS78
|
4.2
|
112.8
|
1.0
|
C
|
d:CYS60
|
4.3
|
112.4
|
1.0
|
N
|
d:GLY63
|
4.4
|
114.8
|
1.0
|
CA
|
d:CYS75
|
4.5
|
114.7
|
1.0
|
C
|
d:CYS62
|
4.5
|
113.6
|
1.0
|
CB
|
d:ARG77
|
4.5
|
113.7
|
1.0
|
C
|
d:TYR61
|
4.6
|
107.6
|
1.0
|
N
|
d:TYR65
|
4.6
|
116.5
|
1.0
|
CA
|
d:LYS64
|
4.7
|
115.7
|
1.0
|
CG2
|
d:VAL80
|
4.7
|
102.7
|
1.0
|
C
|
d:ARG77
|
4.8
|
113.7
|
1.0
|
CA
|
d:TYR61
|
4.8
|
107.6
|
1.0
|
CD1
|
d:TYR65
|
4.9
|
116.5
|
1.0
|
C
|
d:CYS75
|
4.9
|
114.7
|
1.0
|
CD
|
d:LYS64
|
5.0
|
115.7
|
1.0
|
|
Reference:
K.Brodolin,
K.Brodolin.
N/A N/A.
Page generated: Wed Oct 30 09:34:52 2024
|