Atomistry » Zinc » PDB 7pvm-7q4p » 7q28
Atomistry »
  Zinc »
    PDB 7pvm-7q4p »
      7q28 »

Zinc in PDB 7q28: Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012

Enzymatic activity of Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012

All present enzymatic activity of Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012:
3.4.15.1;

Protein crystallography data

The structure of Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012, PDB code: 7q28 was solved by G.E.Cozier, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 71.55 / 1.65
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.254, 84.78, 133.376, 90, 90, 90
R / Rfree (%) 16.3 / 18.3

Other elements in 7q28:

The structure of Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012 (pdb code 7q28). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012, PDB code: 7q28:

Zinc binding site 1 out of 1 in 7q28

Go back to Zinc Binding Sites List in 7q28
Zinc binding site 1 out of 1 in the Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Angiotensin-1 Converting Enzyme C-Domain in Complex with Dual Ace/Nep Inhibitor AD012 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn709

b:18.7
occ:1.00
 OE1 A:GLU411 2.0 19.6 1.0
NE2 A:HIS387 2.0 19.7 1.0
O24 A:8J9703 2.0 19.3 1.0
NE2 A:HIS383 2.0 19.4 1.0
O25 A:8J9703 2.6 21.8 1.0
C23 A:8J9703 2.6 20.5 1.0
CD A:GLU411 2.9 20.0 1.0
CE1 A:HIS387 2.9 21.8 1.0
CE1 A:HIS383 2.9 21.3 1.0
CD2 A:HIS387 3.1 18.7 1.0
CD2 A:HIS383 3.1 21.5 1.0
HE1 A:HIS383 3.1 25.6 1.0
HE1 A:HIS387 3.1 26.2 1.0
OE2 A:GLU411 3.2 21.4 1.0
HE1 A:TYR523 3.2 21.3 1.0
HD2 A:HIS387 3.3 22.4 1.0
HD2 A:HIS383 3.3 25.8 1.0
HO2 A:BO3708 3.3 50.2 1.0
HA A:GLU411 3.7 21.7 1.0
HO3 A:BO3708 3.7 28.1 1.0
H051 A:8J9703 3.8 23.8 1.0
ND1 A:HIS383 4.1 21.0 1.0
ND1 A:HIS387 4.1 21.7 1.0
C22 A:8J9703 4.1 20.5 1.0
O2 A:BO3708 4.1 41.9 1.0
CE1 A:TYR523 4.1 17.8 1.0
CG A:HIS387 4.2 18.7 1.0
CG A:HIS383 4.2 18.5 1.0
CG A:GLU411 4.3 19.2 1.0
H221 A:8J9703 4.4 24.6 1.0
OH A:TYR523 4.4 17.7 1.0
H271 A:8J9703 4.4 26.2 1.0
HB3 A:GLU411 4.4 19.4 1.0
O A:HOH973 4.4 26.3 1.0
O3 A:BO3708 4.5 23.4 1.0
CA A:GLU411 4.5 18.1 1.0
CB A:GLU411 4.6 16.2 1.0
B A:BO3708 4.7 36.4 1.0
OE2 A:GLU384 4.7 21.5 1.0
C05 A:8J9703 4.7 19.8 1.0
HG3 A:GLU411 4.7 23.1 1.0
H022 A:8J9703 4.8 36.4 1.0
CZ A:TYR523 4.8 17.9 1.0
N21 A:8J9703 4.8 23.9 1.0
HD1 A:HIS383 4.8 25.2 1.0
HD1 A:HIS387 4.8 26.1 1.0
HG2 A:GLU411 4.9 23.1 1.0
OE1 A:GLU384 4.9 20.4 1.0

Reference:

L.B.Arendse, G.E.Cozier, C.J.Eyermann, G.S.Basarab, S.L.Schwager, K.Chibale, K.R.Acharya, E.D.Sturrock. Probing the Requirements For Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J.Med.Chem. V. 65 3371 2022.
ISSN: ISSN 0022-2623
PubMed: 35113565
DOI: 10.1021/ACS.JMEDCHEM.1C01924
Page generated: Wed Oct 30 09:33:28 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy