Atomistry » Zinc » PDB 7py5-7q8e » 7pzs
Atomistry »
  Zinc »
    PDB 7py5-7q8e »
      7pzs »

Zinc in PDB 7pzs: Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

Enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

All present enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria:
3.5.1.108;

Protein crystallography data

The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pzs was solved by M.D.Ryan, T.D.Pallin, M.B.A.C.Lamers, P.M.Leonard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.54 / 2.45
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 35.517, 67.43, 62.942, 90, 90.39, 90
R / Rfree (%) 18.5 / 27.5

Other elements in 7pzs:

The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Fluorine (F) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria (pdb code 7pzs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pzs:

Zinc binding site 1 out of 1 in 7pzs

Go back to Zinc Binding Sites List in 7pzs
Zinc binding site 1 out of 1 in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:20.0
occ:1.00
OD1 A:ASP241 2.0 16.8 1.0
NE2 A:HIS237 2.1 21.9 1.0
NE2 A:HIS78 2.1 16.5 1.0
O27 A:98O502 2.1 25.8 1.0
N29 A:98O502 2.1 33.0 1.0
CG A:ASP241 2.7 16.9 1.0
C26 A:98O502 2.7 28.0 1.0
OD2 A:ASP241 2.7 16.2 1.0
C28 A:98O502 2.8 30.9 1.0
CE1 A:HIS78 3.0 16.4 1.0
CD2 A:HIS237 3.0 19.9 1.0
CE1 A:HIS237 3.1 21.5 1.0
CD2 A:HIS78 3.2 16.5 1.0
C30 A:98O502 3.2 35.3 1.0
N1 A:98O502 3.9 27.4 1.0
ND1 A:HIS78 4.1 16.0 1.0
CB A:ASP241 4.2 17.3 1.0
C32 A:98O502 4.2 33.6 1.0
ND1 A:HIS237 4.2 19.9 1.0
CG A:HIS237 4.2 19.1 1.0
CG A:HIS78 4.2 16.1 1.0
C31 A:98O502 4.3 36.3 1.0
OE2 A:GLU77 4.3 27.4 1.0
CB A:THR190 4.4 22.3 1.0
CG A:GLU77 4.5 22.8 1.0
OG1 A:THR190 4.6 21.9 1.0
F33 A:98O502 4.7 44.1 1.0
C2 A:98O502 4.7 29.0 1.0
CA A:THR190 4.8 21.8 1.0
CA A:ASP241 4.9 17.7 1.0
CD2 A:LEU240 4.9 22.5 1.0
CD A:GLU77 5.0 25.2 1.0
O A:HIS237 5.0 17.2 1.0

Reference:

M.D.Ryan, T.D.Pallin, T.Mullins, T.Blench, I.Fraser, J.Dallow, N.Ahmed, C.Ellwood, S.Gaines, J.Flores, Y.Blackwell, C.T.Garcia, G.Spence, A.Reeve, T.Panchal, B.Dominguez-Fernandez, P.M.Leonard, M.B.A.C.Lamers, A.Arduin, C.Fotinou, E.Gancia, D.E.Clark, E.Bush, J.Betts, C.Richards, T.Rea-Davies, A.D.Keefe, Y.Zhang, H.T.Soutter, P.A.Centrella, M.A.Clark, J.W.Cuozzo, C.E.Dumelin, S.Habeshian, A.Hunt, E.A.Sigel, D.M.Troast, B.L.M.Dejonge. Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published.
Page generated: Sat Apr 8 01:45:14 2023

Last articles

Cd in 3CFK
Cd in 3CMA
Cd in 3CME
Cd in 3CJK
Cd in 3CD6
Cd in 3CCV
Cd in 3CEL
Cd in 3CCU
Cd in 3CCS
Cd in 3CCQ
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy