Zinc in PDB 7pk8: Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria
Enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria
All present enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria:
3.5.1.108;
3.5.1.108;
Protein crystallography data
The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pk8
was solved by
M.D.Ryan,
T.D.Pallin,
M.B.A.C.Lamers,
P.M.Leonard,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 45.89 / 2.30 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 35.92, 66.88, 62.98, 90, 90.37, 90 |
| R / Rfree (%) | 20.1 / 26.7 |
Other elements in 7pk8:
The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria
(pdb code 7pk8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pk8:
In total only one binding site of Zinc was determined in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pk8:
Zinc binding site 1 out of 1 in 7pk8
Go back to
Zinc Binding Sites List in 7pk8
Zinc binding site 1 out
of 1 in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria within 5.0Å range:
|
Reference:
M.D.Ryan,
T.D.Pallin,
T.Mullins,
T.Blench,
I.Fraser,
J.Dallow,
N.Ahmed,
C.Ellwood,
S.Gaines,
J.Flores,
Y.Blackwell,
C.T.Garcia,
G.Spence,
A.Reeve,
T.Panchal,
B.Dominguez-Fernandez,
P.M.Leonard,
M.B.A.C.Lamers,
A.Arduin,
C.Fotinou,
E.Gancia,
D.E.Clark,
E.Bush,
J.Betts,
C.Richards,
T.Rea-Davies,
A.D.Keefe,
Y.Zhang,
H.T.Soutter,
P.A.Centrella,
M.A.Clark,
J.W.Cuozzo,
C.E.Dumelin,
S.Habeshian,
A.Hunt,
E.A.Sigel,
D.M.Troast,
B.L.M.Dejonge.
Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published.
Page generated: Wed Oct 30 09:12:30 2024
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