Zinc in PDB 7phl: Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
Other elements in 7phl:
The structure of Human Voltage-Gated Potassium Channel KV3.1 (with Edta) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
(pdb code 7phl). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the
Human Voltage-Gated Potassium Channel KV3.1 (with Edta), PDB code: 7phl:
Jump to Zinc binding site number:
1;
2;
3;
4;
Zinc binding site 1 out
of 4 in 7phl
Go back to
Zinc Binding Sites List in 7phl
Zinc binding site 1 out
of 4 in the Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Human Voltage-Gated Potassium Channel KV3.1 (with Edta) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn603
b:30.0
occ:1.00
|
ND1
|
A:HIS77
|
2.0
|
99.3
|
1.0
|
SG
|
A:CYS104
|
2.3
|
107.9
|
1.0
|
SG
|
A:CYS105
|
2.4
|
105.6
|
1.0
|
CB
|
B:CYS83
|
2.6
|
103.8
|
1.0
|
SG
|
B:CYS83
|
2.6
|
103.8
|
1.0
|
CE1
|
A:HIS77
|
2.9
|
99.3
|
1.0
|
CG
|
A:HIS77
|
3.0
|
99.3
|
1.0
|
CB
|
A:HIS77
|
3.5
|
99.3
|
1.0
|
CB
|
A:CYS104
|
3.8
|
107.9
|
1.0
|
NE2
|
A:HIS77
|
4.0
|
99.3
|
1.0
|
CD2
|
A:HIS77
|
4.1
|
99.3
|
1.0
|
CA
|
B:CYS83
|
4.1
|
103.8
|
1.0
|
CB
|
A:CYS105
|
4.1
|
105.6
|
1.0
|
CA
|
A:HIS77
|
4.3
|
99.3
|
1.0
|
N
|
A:CYS105
|
4.4
|
105.6
|
1.0
|
C
|
A:CYS104
|
4.5
|
107.9
|
1.0
|
CB
|
A:GLU102
|
4.7
|
104.0
|
1.0
|
CA
|
A:CYS104
|
4.7
|
107.9
|
1.0
|
CD
|
B:PRO85
|
4.7
|
98.1
|
1.0
|
CA
|
A:CYS105
|
4.8
|
105.6
|
1.0
|
N
|
B:CYS83
|
4.8
|
103.8
|
1.0
|
C
|
B:CYS83
|
4.8
|
103.8
|
1.0
|
N
|
A:CYS78
|
4.9
|
102.5
|
1.0
|
CG
|
B:PRO85
|
4.9
|
98.1
|
1.0
|
|
Zinc binding site 2 out
of 4 in 7phl
Go back to
Zinc Binding Sites List in 7phl
Zinc binding site 2 out
of 4 in the Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Human Voltage-Gated Potassium Channel KV3.1 (with Edta) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn603
b:30.0
occ:1.00
|
ND1
|
C:HIS77
|
2.2
|
99.3
|
1.0
|
SG
|
C:CYS105
|
2.4
|
105.6
|
1.0
|
SG
|
C:CYS104
|
2.4
|
107.9
|
1.0
|
CB
|
D:CYS83
|
2.6
|
103.8
|
1.0
|
SG
|
D:CYS83
|
2.6
|
103.8
|
1.0
|
CE1
|
C:HIS77
|
3.0
|
99.3
|
1.0
|
CG
|
C:HIS77
|
3.1
|
99.3
|
1.0
|
CB
|
C:HIS77
|
3.5
|
99.3
|
1.0
|
CB
|
C:CYS104
|
3.8
|
107.9
|
1.0
|
CB
|
C:CYS105
|
4.1
|
105.6
|
1.0
|
CA
|
D:CYS83
|
4.1
|
103.8
|
1.0
|
NE2
|
C:HIS77
|
4.1
|
99.3
|
1.0
|
CD2
|
C:HIS77
|
4.2
|
99.3
|
1.0
|
N
|
C:CYS105
|
4.4
|
105.6
|
1.0
|
CA
|
C:HIS77
|
4.4
|
99.3
|
1.0
|
C
|
C:CYS104
|
4.5
|
107.9
|
1.0
|
CA
|
C:CYS104
|
4.7
|
107.9
|
1.0
|
CA
|
C:CYS105
|
4.7
|
105.6
|
1.0
|
CD
|
D:PRO85
|
4.7
|
98.1
|
1.0
|
N
|
D:CYS83
|
4.8
|
103.8
|
1.0
|
CB
|
C:GLU102
|
4.8
|
104.0
|
1.0
|
N
|
C:CYS78
|
4.8
|
102.5
|
1.0
|
C
|
D:CYS83
|
4.8
|
103.8
|
1.0
|
O
|
C:CYS104
|
4.9
|
107.9
|
1.0
|
CG
|
D:PRO85
|
4.9
|
98.1
|
1.0
|
|
Zinc binding site 3 out
of 4 in 7phl
Go back to
Zinc Binding Sites List in 7phl
Zinc binding site 3 out
of 4 in the Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Human Voltage-Gated Potassium Channel KV3.1 (with Edta) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn601
b:30.0
occ:1.00
|
ND1
|
B:HIS77
|
2.0
|
99.3
|
1.0
|
SG
|
B:CYS104
|
2.3
|
107.9
|
1.0
|
SG
|
B:CYS105
|
2.4
|
105.6
|
1.0
|
CB
|
C:CYS83
|
2.6
|
103.8
|
1.0
|
SG
|
C:CYS83
|
2.6
|
103.8
|
1.0
|
CE1
|
B:HIS77
|
2.9
|
99.3
|
1.0
|
CG
|
B:HIS77
|
3.0
|
99.3
|
1.0
|
CB
|
B:HIS77
|
3.5
|
99.3
|
1.0
|
CB
|
B:CYS104
|
3.8
|
107.9
|
1.0
|
NE2
|
B:HIS77
|
4.0
|
99.3
|
1.0
|
CB
|
B:CYS105
|
4.1
|
105.6
|
1.0
|
CD2
|
B:HIS77
|
4.1
|
99.3
|
1.0
|
CA
|
C:CYS83
|
4.1
|
103.8
|
1.0
|
CA
|
B:HIS77
|
4.3
|
99.3
|
1.0
|
N
|
B:CYS105
|
4.4
|
105.6
|
1.0
|
C
|
B:CYS104
|
4.5
|
107.9
|
1.0
|
CB
|
B:GLU102
|
4.7
|
104.0
|
1.0
|
CA
|
B:CYS104
|
4.7
|
107.9
|
1.0
|
CD
|
C:PRO85
|
4.7
|
98.1
|
1.0
|
CA
|
B:CYS105
|
4.7
|
105.6
|
1.0
|
N
|
C:CYS83
|
4.8
|
103.8
|
1.0
|
N
|
B:CYS78
|
4.8
|
102.5
|
1.0
|
C
|
C:CYS83
|
4.8
|
103.8
|
1.0
|
CG
|
C:PRO85
|
4.9
|
98.1
|
1.0
|
O
|
B:CYS104
|
5.0
|
107.9
|
1.0
|
|
Zinc binding site 4 out
of 4 in 7phl
Go back to
Zinc Binding Sites List in 7phl
Zinc binding site 4 out
of 4 in the Human Voltage-Gated Potassium Channel KV3.1 (with Edta)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Human Voltage-Gated Potassium Channel KV3.1 (with Edta) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn601
b:30.0
occ:1.00
|
ND1
|
D:HIS77
|
2.0
|
99.3
|
1.0
|
SG
|
D:CYS105
|
2.2
|
105.6
|
1.0
|
SG
|
D:CYS104
|
2.3
|
107.9
|
1.0
|
CB
|
A:CYS83
|
2.6
|
103.8
|
1.0
|
SG
|
A:CYS83
|
2.6
|
103.8
|
1.0
|
CE1
|
D:HIS77
|
2.9
|
99.3
|
1.0
|
CG
|
D:HIS77
|
3.0
|
99.3
|
1.0
|
CB
|
D:HIS77
|
3.4
|
99.3
|
1.0
|
CB
|
D:CYS104
|
3.8
|
107.9
|
1.0
|
CB
|
D:CYS105
|
4.0
|
105.6
|
1.0
|
NE2
|
D:HIS77
|
4.0
|
99.3
|
1.0
|
CD2
|
D:HIS77
|
4.1
|
99.3
|
1.0
|
CA
|
A:CYS83
|
4.1
|
103.8
|
1.0
|
CA
|
D:HIS77
|
4.2
|
99.3
|
1.0
|
N
|
D:CYS105
|
4.3
|
105.6
|
1.0
|
C
|
D:CYS104
|
4.4
|
107.9
|
1.0
|
CB
|
D:GLU102
|
4.6
|
104.0
|
1.0
|
CA
|
D:CYS105
|
4.6
|
105.6
|
1.0
|
CA
|
D:CYS104
|
4.6
|
107.9
|
1.0
|
CD
|
A:PRO85
|
4.7
|
98.1
|
1.0
|
N
|
D:CYS78
|
4.7
|
102.5
|
1.0
|
N
|
A:CYS83
|
4.8
|
103.8
|
1.0
|
C
|
A:CYS83
|
4.8
|
103.8
|
1.0
|
O
|
D:CYS104
|
4.9
|
107.9
|
1.0
|
CG
|
A:PRO85
|
4.9
|
98.1
|
1.0
|
|
Reference:
G.Chi,
Q.Liang,
A.Sridhar,
J.B.Cowgill,
K.Sader,
M.Radjainia,
P.Qian,
P.Castro-Hartmann,
S.Venkaya,
N.K.Singh,
G.Mckinley,
A.Fernandez-Cid,
S.M.M.Mukhopadhyay,
N.A.Burgess-Brown,
L.Delemotte,
M.Covarrubias,
K.L.Durr.
Cryo-Em Structure of the Human KV3.1 Channel Reveals Gating Control By the Cytoplasmic T1 Domain. Nat Commun V. 13 4087 2022.
ISSN: ESSN 2041-1723
PubMed: 35840580
DOI: 10.1038/S41467-022-29594-W
Page generated: Wed Oct 30 09:11:59 2024
|