Zinc in PDB 7pab: Varicella Zoster ORF24-ORF27 Nuclear Egress Complex

The structure of Varicella Zoster ORF24-ORF27 Nuclear Egress Complex, PDB code: 7pab was solved by J.Schweininger, Y.A.Muller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.96 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	76.01, 35.05, 158.22, 90, 93.69, 90
R / Rfree (%)	21.5 / 25.4

The binding sites of Zinc atom in the Varicella Zoster ORF24-ORF27 Nuclear Egress Complex (pdb code 7pab). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Varicella Zoster ORF24-ORF27 Nuclear Egress Complex, PDB code: 7pab:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Varicella Zoster ORF24-ORF27 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Varicella Zoster ORF24-ORF27 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:54.6 occ:1.00 NE2 A:HIS1251 2.1 84.2 1.0 SG A:CYS1147 2.3 63.4 1.0 SG A:CYS1128 2.3 50.6 1.0 SG A:CYS1144 2.3 63.5 1.0 HB2 A:CYS1128 2.8 60.1 1.0 CB A:CYS1128 2.9 50.1 1.0 HB3 A:CYS1128 2.9 60.1 1.0 HB3 A:CYS1144 2.9 78.7 1.0 CE1 A:HIS1251 3.0 81.2 1.0 H A:CYS1147 3.1 91.0 1.0 CB A:CYS1144 3.1 65.5 1.0 HE1 A:HIS1251 3.1 97.5 1.0 CD2 A:HIS1251 3.1 78.3 1.0 HB2 A:CYS1147 3.2 84.4 1.0 HB2 A:CYS1144 3.2 78.7 1.0 CB A:CYS1147 3.3 70.3 1.0 HD2 A:HIS1251 3.4 94.0 1.0 HB A:THR1146 3.7 82.3 1.0 N A:CYS1147 3.7 75.8 1.0 CA A:CYS1147 4.0 78.3 1.0 HB3 A:CYS1147 4.1 84.4 1.0 ND1 A:HIS1251 4.1 78.4 1.0 HA2 A:GLY1141 4.2 74.5 1.0 HA A:CYS1147 4.2 94.0 1.0 CG A:HIS1251 4.2 74.1 1.0 HA A:HIS1253 4.3 62.5 1.0 CA A:CYS1128 4.4 48.7 1.0 CA A:CYS1144 4.5 68.8 1.0 CB A:THR1146 4.6 68.6 1.0 HA3 A:GLY1139 4.7 63.6 1.0 C A:THR1146 4.8 75.4 1.0 H A:TYR1254 4.8 63.0 1.0 H A:CYS1128 4.8 58.9 1.0 H A:THR1146 4.8 87.9 1.0 HD2 A:TYR1254 4.9 73.5 1.0 HD1 A:HIS1251 4.9 94.1 1.0 HA A:CYS1128 4.9 58.5 1.0 HA A:CYS1144 5.0 82.6 1.0 C A:CYS1144 5.0 70.1 1.0 C A:CYS1128 5.0 48.7 1.0

Zinc binding site 2 out of 2 in the Varicella Zoster ORF24-ORF27 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Varicella Zoster ORF24-ORF27 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn501 b:49.2 occ:1.00 NE2 C:HIS1251 2.1 74.7 1.0 SG C:CYS1147 2.2 54.1 1.0 SG C:CYS1144 2.3 49.2 1.0 SG C:CYS1128 2.3 48.7 1.0 HB3 C:CYS1144 2.9 63.6 1.0 HB2 C:CYS1128 2.9 53.1 1.0 CE1 C:HIS1251 3.0 72.3 1.0 H C:CYS1147 3.0 69.3 1.0 CB C:CYS1144 3.0 53.0 1.0 CB C:CYS1128 3.0 44.2 1.0 HE1 C:HIS1251 3.1 86.8 1.0 HB3 C:CYS1128 3.1 53.1 1.0 CD2 C:HIS1251 3.1 70.9 1.0 HB2 C:CYS1144 3.2 63.6 1.0 HD2 C:HIS1251 3.4 85.2 1.0 HB C:THR1146 3.5 68.2 1.0 CB C:CYS1147 3.5 55.7 1.0 HB2 C:CYS1147 3.6 66.9 1.0 N C:CYS1147 3.6 57.7 1.0 CA C:CYS1147 4.0 56.9 1.0 ND1 C:HIS1251 4.1 70.0 1.0 HA2 C:GLY1141 4.2 67.0 1.0 O C:HOH621 4.2 46.4 1.0 HA C:CYS1147 4.2 68.4 1.0 CG C:HIS1251 4.2 67.4 1.0 HB3 C:CYS1147 4.3 66.9 1.0 H C:THR1146 4.4 68.5 1.0 CB C:THR1146 4.4 56.8 1.0 CA C:CYS1144 4.5 56.6 1.0 HA C:HIS1253 4.5 51.3 1.0 CA C:CYS1128 4.5 42.1 1.0 C C:THR1146 4.6 58.8 1.0 HA3 C:GLY1139 4.7 60.4 1.0 HG C:SER1130 4.8 60.1 1.0 OG C:SER1130 4.9 50.0 1.0 CA C:THR1146 4.9 58.6 1.0 N C:THR1146 4.9 57.1 1.0 HG22 C:THR1146 4.9 67.8 1.0 HD1 C:HIS1251 4.9 84.0 1.0 HD2 C:TYR1254 4.9 59.0 1.0 C C:CYS1144 4.9 56.8 1.0 HA C:CYS1144 4.9 68.0 1.0 H C:CYS1128 4.9 51.8 1.0

J.Schweininger, M.Kriegel, S.Hage, M.Conrad, S.Alkhashrom, J.Losing, S.Weiler, J.Tillmanns, C.Egerer-Sieber, A.Decker, T.Lenac Rovis, J.Eichler, H.Sticht, M.Marschall, Y.A.Muller. The Crystal Structure of the Varicella-Zoster ORF24-ORF27 Nuclear Egress Complex Spotlights Multiple Determinants of Herpesvirus Subfamily Specificity. J.Biol.Chem. V. 298 01625 2022.
ISSN: ESSN 1083-351X
PubMed: 35074430
DOI: 10.1016/J.JBC.2022.101625