Zinc in PDB 7nx4: Crystal Structure of the Tg and Egf-Like Domains of Alk

All present enzymatic activity of Crystal Structure of the Tg and Egf-Like Domains of Alk:
2.7.10.1;

The structure of Crystal Structure of the Tg and Egf-Like Domains of Alk, PDB code: 7nx4 was solved by S.De Munck, S.N.Savvides, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	60.05 / 3.00
Space group	I 41
Cell size a, b, c (Å), α, β, γ (°)	84.93, 84.93, 148.666, 90, 90, 90
R / Rfree (%)	21.9 / 24.7

The structure of Crystal Structure of the Tg and Egf-Like Domains of Alk also contains other interesting chemical elements:

Nickel

(Ni)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of the Tg and Egf-Like Domains of Alk (pdb code 7nx4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Tg and Egf-Like Domains of Alk, PDB code: 7nx4:

Zinc binding site 1 out of 1 in the Crystal Structure of the Tg and Egf-Like Domains of Alk


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Tg and Egf-Like Domains of Alk within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1105 b:80.3 occ:1.00 OD1 A:ASP732 2.0 138.3 1.0 NE2 A:HIS983 2.1 105.8 1.0 OD2 A:ASP732 2.3 124.7 1.0 CG A:ASP732 2.4 117.2 1.0 CE1 A:HIS983 3.0 95.7 1.0 CD2 A:HIS983 3.0 91.3 1.0 CB A:ASP732 3.9 82.0 1.0 ND1 A:HIS983 4.1 100.9 1.0 CG A:HIS983 4.1 95.0 1.0 N A:THR733 4.2 102.3 1.0 OG1 A:THR733 4.6 89.0 1.0 CA A:ASP732 4.7 96.0 1.0 O A:THR733 4.8 79.2 1.0 O A:TYR984 4.8 85.8 1.0 CB A:THR733 4.9 85.2 1.0 C A:ASP732 5.0 96.9 1.0

S.De Munck, M.Provost, M.Kurikawa, I.Omori, J.Mukohyama, J.Felix, Y.Bloch, O.Abdel-Wahab, J.F.Bazan, A.Yoshimi, S.N.Savvides. Structural Basis of Cytokine-Mediated Activation of Alk Family Receptors. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 34646012
DOI: 10.1038/S41586-021-03959-5