Zinc in PDB 7niq: Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)

Enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)

All present enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class):
3.6.4.13;

Other elements in 7niq:

The structure of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Aluminium (Al) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) (pdb code 7niq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class), PDB code: 7niq:

Zinc binding site 1 out of 1 in 7niq

Go back to Zinc Binding Sites List in 7niq
Zinc binding site 1 out of 1 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1103

b:144.0
occ:1.00
SG B:CYS910 2.3 114.2 1.0
SG B:CYS964 2.3 123.4 1.0
SG B:CYS962 2.3 121.2 1.0
SG B:CYS907 2.3 111.8 1.0
CB B:CYS907 3.2 111.8 1.0
CB B:CYS962 3.4 121.2 1.0
CB B:CYS910 3.5 114.2 1.0
N B:CYS910 3.8 114.2 1.0
CB B:CYS964 3.8 123.4 1.0
O B:CYS910 4.1 114.2 1.0
N B:CYS964 4.1 123.4 1.0
CA B:CYS910 4.1 114.2 1.0
CB B:GLN966 4.3 117.2 1.0
CZ2 B:TRP968 4.3 114.3 1.0
C B:CYS910 4.6 114.2 1.0
CA B:CYS964 4.6 123.4 1.0
CA B:CYS907 4.6 111.8 1.0
NE1 B:TRP968 4.7 114.3 1.0
CB B:ASN909 4.7 114.3 1.0
N B:LYS963 4.8 124.1 1.0
CA B:CYS962 4.8 121.2 1.0
CE2 B:TRP968 4.9 114.3 1.0
C B:ASN909 4.9 114.3 1.0

Reference:

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5
Page generated: Thu Nov 25 10:56:57 2021

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