Zinc in PDB 7nga: Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist

All present enzymatic activity of Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist:
3.6.4.13;

The binding sites of Zinc atom in the Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist (pdb code 7nga). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist, PDB code: 7nga:

Zinc binding site 1 out of 1 in the Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of the MDA5-Dsrna Filament in Complex with Adp with 88-Degree Helical Twist within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:234.0 occ:1.00 SG A:CYS910 2.3 198.3 1.0 SG A:CYS907 2.3 190.6 1.0 SG A:CYS964 2.3 194.2 1.0 SG A:CYS962 2.3 192.9 1.0 CB A:CYS964 3.1 194.2 1.0 H A:CYS910 3.1 198.3 1.0 HB3 A:GLN966 3.1 191.2 1.0 CB A:CYS907 3.4 190.6 1.0 HB3 A:CYS962 3.4 192.9 1.0 CB A:CYS962 3.4 192.9 1.0 HB2 A:GLN966 3.6 191.2 1.0 HB2 A:CYS962 3.6 192.9 1.0 HB2 A:ASN909 3.6 195.3 1.0 CB A:CYS910 3.7 198.3 1.0 HB3 A:CYS910 3.8 198.3 1.0 CB A:GLN966 3.8 191.2 1.0 HE1 A:TRP968 3.9 181.1 1.0 N A:CYS964 3.9 194.2 1.0 N A:CYS910 3.9 198.3 1.0 HZ2 A:TRP968 3.9 181.1 1.0 H A:GLN966 3.9 191.2 1.0 CA A:CYS964 4.0 194.2 1.0 HG2 A:GLN966 4.3 191.2 1.0 CA A:CYS910 4.3 198.3 1.0 O A:CYS910 4.4 198.3 1.0 HB2 A:CYS910 4.5 198.3 1.0 H A:ASN909 4.5 195.3 1.0 CB A:ASN909 4.5 195.3 1.0 NE1 A:TRP968 4.6 181.1 1.0 H A:LYS963 4.6 195.1 1.0 HG2 A:MET912 4.6 188.8 1.0 CG A:GLN966 4.6 191.2 1.0 C A:CYS964 4.7 194.2 1.0 CZ2 A:TRP968 4.7 181.1 1.0 N A:GLN966 4.7 191.2 1.0 HB3 A:ASN909 4.7 195.3 1.0 CA A:CYS907 4.8 190.6 1.0 CA A:CYS962 4.8 192.9 1.0 C A:CYS910 4.8 198.3 1.0 N A:LYS963 4.8 195.1 1.0 CA A:GLN966 4.9 191.2 1.0 C A:ASN909 4.9 195.3 1.0 HD22 A:ASN909 4.9 195.3 1.0 C A:LYS963 5.0 195.1 1.0 CE2 A:TRP968 5.0 181.1 1.0

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5