Zinc in PDB 7lw4: Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah)

The structure of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah), PDB code: 7lw4 was solved by Y.K.Gupta, T.Viswanathan, A.Misra, S.Qi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.75 / 2.50
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	184.589, 184.589, 56.961, 90, 90, 120
R / Rfree (%)	20.4 / 24.1

The binding sites of Zinc atom in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah) (pdb code 7lw4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah), PDB code: 7lw4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:52.0 occ:1.00 NE2 B:HIS83 2.3 97.3 1.0 SG B:CYS90 2.4 59.7 1.0 SG B:CYS77 2.4 48.4 1.0 SG B:CYS74 2.4 57.1 1.0 HE1 B:HIS83 3.0 142.2 1.0 CE1 B:HIS83 3.0 118.4 1.0 H B:CYS77 3.2 82.5 1.0 HB2 B:CYS90 3.3 112.5 1.0 CD2 B:HIS83 3.5 94.8 1.0 HB3 B:CYS74 3.5 67.0 1.0 CB B:CYS90 3.5 93.7 1.0 CB B:CYS77 3.6 66.2 1.0 CB B:CYS74 3.6 55.7 1.0 HB2 B:CYS77 3.7 79.6 1.0 HD2 B:HIS83 3.7 113.9 1.0 HB2 B:TYR76 3.8 87.0 1.0 N B:CYS77 3.8 68.7 1.0 HB2 B:CYS74 3.9 67.0 1.0 HB3 B:CYS90 4.1 112.5 1.0 CA B:CYS77 4.2 71.2 1.0 HA B:CYS77 4.2 85.6 1.0 ND1 B:HIS83 4.3 111.2 1.0 HA B:CYS90 4.4 126.3 1.0 HB3 B:CYS77 4.4 79.6 1.0 CG B:HIS83 4.5 95.9 1.0 HD1 B:TYR76 4.5 88.9 1.0 HB2 B:LYS93 4.6 70.7 1.0 CA B:CYS90 4.6 105.1 1.0 CB B:TYR76 4.7 72.3 1.0 C B:TYR76 4.8 73.3 1.0 H B:TYR76 4.9 81.9 1.0 H B:LYS93 4.9 69.0 1.0 HB2 B:LEU92 4.9 81.2 1.0 HD1 B:HIS83 5.0 133.6 1.0

Zinc binding site 2 out of 2 in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of S-Adenosyl- L-Homocysteine (Sah) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:92.1 occ:1.00 SG B:CYS130 2.3 111.8 1.0 SG B:CYS117 2.4 111.1 1.0 SG B:CYS128 2.4 125.2 1.0 SG B:CYS120 2.4 106.1 1.0 HB2 B:CYS130 3.2 142.3 1.0 H B:CYS120 3.3 130.5 1.0 CB B:CYS130 3.5 118.4 1.0 HB B:VAL119 3.5 140.7 1.0 HB2 B:CYS128 3.5 125.7 1.0 HB3 B:CYS117 3.5 121.5 1.0 CB B:CYS117 3.5 101.1 1.0 CB B:CYS128 3.6 104.6 1.0 HB2 B:CYS117 3.6 121.5 1.0 HB3 B:CYS120 3.7 120.2 1.0 CB B:CYS120 3.7 100.1 1.0 H B:CYS130 3.8 144.0 1.0 N B:CYS120 3.9 108.6 1.0 HB3 B:CYS130 4.1 142.3 1.0 H B:SER129 4.2 127.3 1.0 HA B:CYS128 4.3 130.8 1.0 H B:VAL119 4.3 122.8 1.0 N B:CYS130 4.3 119.9 1.0 HB3 B:CYS128 4.4 125.7 1.0 CB B:VAL119 4.4 117.1 1.0 CA B:CYS120 4.5 110.5 1.0 HB2 B:CYS120 4.5 120.2 1.0 CA B:CYS128 4.5 108.8 1.0 CA B:CYS130 4.5 122.1 1.0 N B:SER129 4.6 106.0 1.0 H B:GLY121 4.8 115.6 1.0 C B:VAL119 4.9 111.0 1.0 C B:CYS128 4.9 111.8 1.0 HA B:CYS130 4.9 146.7 1.0 HG11 B:VAL119 5.0 125.6 1.0 CA B:CYS117 5.0 93.8 1.0

Y.K.Gupta, T.Viswanathan, A.Misra, S.Qi. Structure of Protein-Cap Complex To Be Published.