Zinc in PDB 7lw3: Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah

The structure of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah, PDB code: 7lw3 was solved by Y.K.Gupta, T.Viswanathan, A.Misra, S.Qi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.71 / 2.30
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	184.073, 184.073, 57.128, 90, 90, 120
R / Rfree (%)	22.2 / 25.1

The structure of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah (pdb code 7lw3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah, PDB code: 7lw3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:57.7 occ:1.00 NE2 B:HIS83 2.3 69.5 1.0 SG B:CYS90 2.4 57.7 1.0 SG B:CYS77 2.4 54.1 1.0 SG B:CYS74 2.4 54.5 1.0 CE1 B:HIS83 3.0 64.6 1.0 CB B:CYS90 3.5 73.4 1.0 CD2 B:HIS83 3.5 66.8 1.0 CB B:CYS74 3.6 53.0 1.0 CB B:CYS77 3.7 63.4 1.0 N B:CYS77 4.0 55.8 1.0 ND1 B:HIS83 4.3 65.2 1.0 CA B:CYS77 4.3 55.1 1.0 CG B:HIS83 4.5 76.4 1.0 CA B:CYS90 4.7 78.2 1.0 CB B:TYR76 4.8 58.3 1.0 C B:TYR76 5.0 64.1 1.0

Zinc binding site 2 out of 2 in the Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Sars-Cov-2 NSP16/NSP10 Complex in Presence of Cap-1 Analog (M7GPPPAMU) and Sah within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn203 b:85.6 occ:1.00 SG B:CYS130 2.3 122.4 1.0 SG B:CYS128 2.3 101.9 1.0 SG B:CYS117 2.4 87.5 1.0 SG B:CYS120 2.4 87.2 1.0 CB B:CYS130 3.4 129.6 1.0 CB B:CYS117 3.5 99.7 1.0 CB B:CYS120 3.6 89.4 1.0 CB B:CYS128 3.7 93.9 1.0 N B:CYS120 4.1 101.1 1.0 CA B:CYS120 4.4 96.3 1.0 CA B:CYS128 4.5 97.5 1.0 CA B:CYS130 4.6 133.2 1.0 N B:CYS130 4.7 125.2 1.0 CA B:CYS117 4.9 100.2 1.0 C B:VAL119 5.0 99.9 1.0

Y.K.Gupta, T.Viswanathan, A.Misra, S.Qi. Structure of Protein-Cap Complex To Be Published.