Zinc in PDB 7lhf: Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State (pdb code 7lhf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State, PDB code: 7lhf:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7lhf

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Zinc binding site 1 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2808

b:48.5
occ:1.00
SG A:CYS2611 2.3 33.1 1.0
NE2 A:HIS2631 2.3 40.2 1.0
ND1 A:HIS2636 2.3 37.2 1.0
CB A:CYS2614 2.5 36.2 1.0
CD2 A:HIS2631 3.0 40.2 1.0
CB A:CYS2611 3.1 33.1 1.0
CG A:HIS2636 3.2 37.2 1.0
CE1 A:HIS2636 3.3 37.2 1.0
CB A:HIS2636 3.4 37.2 1.0
CE1 A:HIS2631 3.4 40.2 1.0
N A:CYS2614 3.5 36.2 1.0
CA A:CYS2614 3.6 36.2 1.0
SG A:CYS2614 3.7 36.2 1.0
CG A:HIS2631 4.3 40.2 1.0
CD2 A:HIS2636 4.4 37.2 1.0
NE2 A:HIS2636 4.4 37.2 1.0
ND1 A:HIS2631 4.4 40.2 1.0
CA A:CYS2611 4.6 33.1 1.0
C A:CYS2614 4.6 36.2 1.0
C A:ILE2613 4.8 29.4 1.0
N A:GLY2615 4.8 40.8 1.0
CA A:HIS2636 4.9 37.2 1.0

Zinc binding site 2 out of 4 in 7lhf

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Zinc binding site 2 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn5101

b:48.6
occ:1.00
SG D:CYS2611 2.3 32.5 1.0
NE2 D:HIS2631 2.3 40.4 1.0
ND1 D:HIS2636 2.3 37.8 1.0
CB D:CYS2614 2.5 35.8 1.0
CD2 D:HIS2631 3.0 40.4 1.0
CB D:CYS2611 3.1 32.5 1.0
CG D:HIS2636 3.2 37.8 1.0
CE1 D:HIS2636 3.3 37.8 1.0
CB D:HIS2636 3.4 37.8 1.0
CE1 D:HIS2631 3.4 40.4 1.0
N D:CYS2614 3.5 35.8 1.0
CA D:CYS2614 3.6 35.8 1.0
SG D:CYS2614 3.7 35.8 1.0
CG D:HIS2631 4.3 40.4 1.0
CD2 D:HIS2636 4.4 37.8 1.0
NE2 D:HIS2636 4.4 37.8 1.0
ND1 D:HIS2631 4.4 40.4 1.0
CA D:CYS2611 4.6 32.5 1.0
C D:CYS2614 4.6 35.8 1.0
C D:ILE2613 4.8 29.1 1.0
N D:GLY2615 4.8 39.3 1.0
CA D:HIS2636 4.9 37.8 1.0

Zinc binding site 3 out of 4 in 7lhf

Go back to Zinc Binding Sites List in 7lhf
Zinc binding site 3 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn2808

b:47.2
occ:1.00
SG B:CYS2611 2.3 32.4 1.0
NE2 B:HIS2631 2.3 39.9 1.0
ND1 B:HIS2636 2.3 37.5 1.0
CB B:CYS2614 2.5 35.4 1.0
CD2 B:HIS2631 3.0 39.9 1.0
CB B:CYS2611 3.1 32.4 1.0
CG B:HIS2636 3.2 37.5 1.0
CE1 B:HIS2636 3.3 37.5 1.0
CB B:HIS2636 3.4 37.5 1.0
CE1 B:HIS2631 3.4 39.9 1.0
N B:CYS2614 3.5 35.4 1.0
CA B:CYS2614 3.6 35.4 1.0
SG B:CYS2614 3.7 35.4 1.0
CG B:HIS2631 4.3 39.9 1.0
CD2 B:HIS2636 4.4 37.5 1.0
NE2 B:HIS2636 4.4 37.5 1.0
ND1 B:HIS2631 4.4 39.9 1.0
CA B:CYS2611 4.6 32.4 1.0
C B:CYS2614 4.6 35.4 1.0
C B:ILE2613 4.8 28.9 1.0
N B:GLY2615 4.8 39.0 1.0
CA B:HIS2636 4.9 37.5 1.0

Zinc binding site 4 out of 4 in 7lhf

Go back to Zinc Binding Sites List in 7lhf
Zinc binding site 4 out of 4 in the Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Full-Length IP3R1 Channel Solubilized in Lnmg & Lipid in the Apo-State within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn5101

b:45.9
occ:1.00
NE2 C:HIS2631 2.3 40.3 1.0
SG C:CYS2611 2.3 32.1 1.0
ND1 C:HIS2636 2.3 37.7 1.0
CB C:CYS2614 2.5 35.2 1.0
CD2 C:HIS2631 3.0 40.3 1.0
CB C:CYS2611 3.1 32.1 1.0
CG C:HIS2636 3.2 37.7 1.0
CE1 C:HIS2636 3.3 37.7 1.0
CB C:HIS2636 3.4 37.7 1.0
CE1 C:HIS2631 3.4 40.3 1.0
N C:CYS2614 3.5 35.2 1.0
CA C:CYS2614 3.6 35.2 1.0
SG C:CYS2614 3.7 35.2 1.0
CG C:HIS2631 4.3 40.3 1.0
CD2 C:HIS2636 4.4 37.7 1.0
NE2 C:HIS2636 4.4 37.7 1.0
ND1 C:HIS2631 4.4 40.3 1.0
CA C:CYS2611 4.6 32.1 1.0
C C:CYS2614 4.6 35.2 1.0
N C:GLY2615 4.8 39.5 1.0
C C:ILE2613 4.8 28.7 1.0
CA C:HIS2636 4.9 37.7 1.0

Reference:

M.R.Baker, G.Fan, A.B.Seryshev, M.A.Agosto, M.L.Baker, I.I.Serysheva. Cryo-Em Structure of Type 1 IP3R Channel in A Lipid Bilayer Commun Biol V. 4 625 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-02156-4
Page generated: Mon Jul 12 17:20:50 2021

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