Zinc in PDB 7f9b: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95, PDB code: 7f9b was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.48 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	70.73, 90.96, 83.49, 90, 110.03, 90
R / Rfree (%)	18.9 / 23.6

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 also contains other interesting chemical elements:

Chlorine	(Cl)	3 atoms
Calcium	(Ca)	6 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 (pdb code 7f9b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95, PDB code: 7f9b:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:68.6 occ:0.96 SG A:CYS1448 2.2 54.6 1.0 SG A:CYS1495 2.3 59.2 1.0 SG A:CYS1453 2.4 59.7 1.0 SG A:CYS1497 2.4 71.2 1.0 CB A:CYS1448 3.2 57.9 1.0 CB A:CYS1495 3.3 47.9 1.0 CB A:CYS1497 3.4 65.8 1.0 CB A:CYS1453 3.4 57.5 1.0 N A:CYS1448 4.1 46.6 1.0 N A:CYS1497 4.2 65.8 1.0 CA A:CYS1448 4.3 57.7 1.0 ND2 A:ASN1500 4.3 74.8 1.0 CA A:CYS1497 4.4 60.3 1.0 CA A:CYS1495 4.6 51.1 1.0 CD1 A:PHE1447 4.7 45.3 1.0 CE1 A:PHE1447 4.7 54.7 1.0 CB A:ASN1500 4.8 63.0 1.0 CA A:CYS1453 4.9 53.5 1.0 C A:CYS1495 4.9 55.1 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1902 b:44.0 occ:0.87 SG B:CYS1453 2.3 49.7 1.0 SG B:CYS1448 2.3 50.7 1.0 SG B:CYS1495 2.4 43.7 1.0 SG B:CYS1497 2.4 54.1 1.0 CB B:CYS1497 2.9 49.9 1.0 CB B:CYS1453 3.2 52.4 1.0 CB B:CYS1495 3.3 44.9 1.0 CB B:CYS1448 3.3 43.9 1.0 N B:CYS1448 3.9 44.7 1.0 N B:CYS1497 4.0 55.9 1.0 CA B:CYS1497 4.0 53.2 1.0 CA B:CYS1448 4.2 44.5 1.0 CE1 B:PHE1447 4.4 46.5 1.0 CD1 B:PHE1447 4.4 49.3 1.0 ND2 B:ASN1500 4.5 53.5 1.0 CA B:CYS1453 4.7 52.2 1.0 CA B:CYS1495 4.7 46.9 1.0 C B:CYS1495 5.0 46.5 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.