Zinc in PDB 7f99: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f99 was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	78.25 / 1.98
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	70.471, 91.518, 83.335, 90, 110.11, 90
R / Rfree (%)	18.1 / 22.8

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 also contains other interesting chemical elements:

Chlorine	(Cl)	3 atoms
Fluorine	(F)	2 atoms
Calcium	(Ca)	4 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 (pdb code 7f99). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f99:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:50.4 occ:0.74 SG A:CYS1448 2.3 56.6 1.0 SG A:CYS1453 2.4 55.8 1.0 SG A:CYS1495 2.4 55.3 1.0 SG A:CYS1497 2.5 69.0 1.0 CB A:CYS1448 3.0 56.0 1.0 CB A:CYS1497 3.1 67.6 1.0 CB A:CYS1453 3.2 55.1 1.0 CB A:CYS1495 3.4 49.2 1.0 N A:CYS1448 3.9 57.2 1.0 N A:CYS1497 4.0 68.9 1.0 CA A:CYS1448 4.0 58.1 1.0 CA A:CYS1497 4.2 70.6 1.0 CD1 A:PHE1447 4.4 46.9 1.0 CE1 A:PHE1447 4.4 51.3 1.0 ND2 A:ASN1500 4.7 81.1 1.0 CA A:CYS1453 4.7 49.7 1.0 CA A:CYS1495 4.8 52.5 1.0 C A:CYS1448 4.9 52.4 1.0 N A:VAL1496 5.0 58.4 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1902 b:54.5 occ:0.99 SG B:CYS1453 2.3 54.7 1.0 SG B:CYS1448 2.3 54.0 1.0 SG B:CYS1495 2.5 49.8 1.0 SG B:CYS1497 2.5 57.0 1.0 CB B:CYS1453 3.2 52.5 1.0 CB B:CYS1497 3.2 60.2 1.0 CB B:CYS1495 3.3 43.0 1.0 CB B:CYS1448 3.3 41.5 1.0 N B:CYS1448 4.0 42.8 1.0 N B:CYS1497 4.1 69.5 1.0 CA B:CYS1448 4.3 45.4 1.0 CA B:CYS1497 4.3 65.5 1.0 CE1 B:PHE1447 4.3 49.1 1.0 CD1 B:PHE1447 4.4 46.9 1.0 OD1 B:ASN1500 4.6 67.1 1.0 CA B:CYS1453 4.6 50.2 1.0 CA B:CYS1495 4.7 49.8 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.