Zinc in PDB 7eiz: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading

Enzymatic activity of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading

All present enzymatic activity of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading:
2.7.7.48;

Other elements in 7eiz:

The structure of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 13;

Binding sites:

The binding sites of Zinc atom in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading (pdb code 7eiz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 13 binding sites of Zinc where determined in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading, PDB code: 7eiz:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 13 in 7eiz

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Zinc binding site 1 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:138.0
occ:1.00
NE2 A:HIS295 2.0 98.2 1.0
SG A:CYS306 2.3 81.6 1.0
SG A:CYS310 2.3 84.8 1.0
SG A:CYS301 2.3 83.6 1.0
CD2 A:HIS295 2.7 98.2 1.0
CE1 A:HIS295 2.8 98.2 1.0
O A:CYS306 3.1 81.6 1.0
CB A:CYS306 3.6 81.6 1.0
CB A:CYS310 3.6 84.8 1.0
CG A:HIS295 3.6 98.2 1.0
CB A:CYS301 3.6 83.6 1.0
ND1 A:HIS295 3.7 98.2 1.0
C A:CYS306 3.8 81.6 1.0
CA A:CYS306 4.1 81.6 1.0
CA A:CYS301 4.1 83.6 1.0
ND1 A:HIS309 4.6 75.6 1.0
N A:CYS310 4.6 84.8 1.0
N A:HIS295 4.7 98.2 1.0
N A:ILE307 4.7 75.1 1.0
CA A:CYS310 4.7 84.8 1.0
N A:CYS301 4.9 83.6 1.0
CB A:HIS295 4.9 98.2 1.0
O A:THR293 4.9 88.7 1.0

Zinc binding site 2 out of 13 in 7eiz

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Zinc binding site 2 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1002

b:151.1
occ:1.00
CE1 A:HIS642 1.6 104.3 1.0
ND1 A:HIS642 2.0 104.3 1.0
N A:CYS646 2.3 109.8 1.0
SG A:CYS645 2.3 111.7 1.0
SG A:CYS487 2.3 104.5 1.0
SG A:CYS646 2.3 109.8 1.0
CB A:CYS645 2.4 111.7 1.0
C A:CYS645 2.6 111.7 1.0
NE2 A:HIS642 2.9 104.3 1.0
CA A:CYS646 3.0 109.8 1.0
CA A:CYS645 3.0 111.7 1.0
CB A:CYS646 3.2 109.8 1.0
CG A:HIS642 3.4 104.3 1.0
O A:CYS645 3.4 111.7 1.0
NZ A:LYS532 3.6 88.3 1.0
CB A:CYS487 3.6 104.5 1.0
CD2 A:HIS642 3.7 104.3 1.0
N A:CYS645 3.9 111.7 1.0
N A:CYS487 3.9 104.5 1.0
O A:HIS642 4.0 104.3 1.0
CE1 A:PHE571 4.4 82.9 1.0
CA A:CYS487 4.4 104.5 1.0
C A:CYS646 4.4 109.8 1.0
CB A:HIS642 4.5 104.3 1.0
CE A:LYS532 4.8 88.3 1.0
C A:THR644 4.8 107.7 1.0
C A:HIS642 4.9 104.3 1.0
O A:CYS646 5.0 109.8 1.0
C A:GLY486 5.0 102.8 1.0
CD1 A:PHE571 5.0 82.9 1.0

Zinc binding site 3 out of 13 in 7eiz

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Zinc binding site 3 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn200

b:1000.0
occ:1.00
CB H:CYS90 1.9 115.8 1.0
SG H:CYS77 2.0 115.8 1.0
NE2 H:HIS83 2.5 115.8 1.0
SG H:CYS74 2.5 115.8 1.0
SG H:CYS90 2.6 115.8 1.0
CE1 H:HIS83 3.4 115.8 1.0
CA H:CYS90 3.4 115.8 1.0
CB H:CYS74 3.5 115.8 1.0
CD2 H:HIS83 3.5 115.8 1.0
CB H:TYR76 3.5 115.8 1.0
N H:CYS77 3.6 115.8 1.0
CB H:CYS77 3.6 115.8 1.0
N H:CYS90 3.8 115.8 1.0
C H:TYR76 4.0 115.8 1.0
CA H:CYS77 4.1 115.8 1.0
CA H:TYR76 4.3 115.8 1.0
C H:CYS90 4.4 115.8 1.0
CG H:TYR76 4.5 115.8 1.0
CD2 H:TYR76 4.5 115.8 1.0
ND1 H:HIS83 4.5 115.8 1.0
CG H:HIS83 4.6 115.8 1.0
OD1 H:ASN85 4.6 115.8 1.0
N H:TYR76 4.7 115.8 1.0
O H:TYR76 4.7 115.8 1.0
CA H:CYS74 4.8 115.8 1.0
C H:PHE89 4.9 115.8 1.0
O H:CYS74 4.9 115.8 1.0
O H:CYS90 5.0 115.8 1.0
C H:CYS74 5.0 115.8 1.0

Zinc binding site 4 out of 13 in 7eiz

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Zinc binding site 4 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn201

b:1000.0
occ:1.00
SG H:CYS120 2.3 115.8 1.0
SG H:CYS130 2.3 115.8 1.0
SG H:CYS117 2.3 115.8 1.0
N H:CYS120 3.5 115.8 1.0
CB H:CYS117 3.5 115.8 1.0
CB H:CYS128 3.5 115.8 1.0
CB H:CYS120 3.7 115.8 1.0
NZ H:LYS124 3.8 115.8 1.0
CB H:VAL119 3.8 115.8 1.0
CB H:CYS130 4.1 115.8 1.0
CA H:CYS120 4.2 115.8 1.0
CG1 H:VAL119 4.3 115.8 1.0
C H:VAL119 4.5 115.8 1.0
CA H:VAL119 4.5 115.8 1.0
CE H:LYS124 4.5 115.8 1.0
CA H:CYS128 4.6 115.8 1.0
SG H:CYS128 4.6 115.8 1.0
N H:VAL119 4.6 115.8 1.0
CD H:LYS124 4.7 115.8 1.0
CG2 H:VAL119 4.7 115.8 1.0
N H:CYS130 4.8 115.8 1.0
CA H:CYS117 4.9 115.8 1.0
CA H:CYS130 4.9 115.8 1.0
C H:CYS120 5.0 115.8 1.0

Zinc binding site 5 out of 13 in 7eiz

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Zinc binding site 5 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn601

b:1000.0
occ:1.00
ND1 K:HIS229 2.1 115.8 1.0
SG K:CYS226 2.3 115.8 1.0
SG K:CYS210 2.3 115.8 1.0
SG K:CYS207 2.3 115.8 1.0
CB K:CYS210 2.9 115.8 1.0
CE1 K:HIS229 3.0 115.8 1.0
CG K:HIS229 3.0 115.8 1.0
CB K:CYS226 3.1 115.8 1.0
N K:CYS226 3.2 115.8 1.0
CB K:HIS229 3.4 115.8 1.0
O K:CYS208 3.5 115.8 1.0
CA K:CYS226 3.7 115.8 1.0
CB K:CYS207 3.9 115.8 1.0
NE2 K:HIS229 4.0 115.8 1.0
CD2 K:HIS229 4.0 115.8 1.0
C K:ALA225 4.2 115.8 1.0
CA K:CYS210 4.2 115.8 1.0
CA K:ALA225 4.3 115.8 1.0
N K:CYS210 4.5 115.8 1.0
C K:CYS226 4.6 115.8 1.0
CA K:HIS229 4.6 115.8 1.0
C K:CYS208 4.6 115.8 1.0
N K:HIS229 4.7 115.8 1.0
N K:TRP227 4.7 115.8 1.0
N K:CYS208 4.7 115.8 1.0
NH1 K:ARG212 4.9 1000.0 1.0
SG K:CYS208 4.9 115.8 1.0
CB K:ALA225 4.9 115.8 1.0
O K:TYR224 4.9 115.8 1.0

Zinc binding site 6 out of 13 in 7eiz

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Zinc binding site 6 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn602

b:1000.0
occ:1.00
NE2 K:HIS264 1.6 115.8 1.0
CE1 K:HIS264 1.7 115.8 1.0
CD2 K:HIS264 2.0 115.8 1.0
ND1 K:HIS264 2.1 115.8 1.0
NE2 K:HIS257 2.1 115.8 1.0
CG K:HIS264 2.2 115.8 1.0
SG K:CYS261 2.3 115.8 1.0
SG K:CYS279 2.3 115.8 1.0
CE1 K:HIS257 2.3 115.8 1.0
CB K:CYS279 3.2 115.8 1.0
CD2 K:HIS257 3.4 115.8 1.0
CB K:HIS264 3.5 115.8 1.0
ND1 K:HIS257 3.6 115.8 1.0
CB K:CYS261 3.7 115.8 1.0
CG K:HIS257 4.2 115.8 1.0
OD1 K:ASP415 4.3 115.8 1.0
CG K:MET276 4.4 115.8 1.0
CA K:CYS279 4.7 115.8 1.0
O K:GLY413 4.7 115.8 1.0
CA K:HIS264 4.7 115.8 1.0
CA K:MET276 4.7 115.8 1.0
N K:HIS264 4.9 115.8 1.0
CA K:CYS261 4.9 115.8 1.0
CB K:MET276 5.0 115.8 1.0

Zinc binding site 7 out of 13 in 7eiz

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Zinc binding site 7 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn603

b:1000.0
occ:1.00
CB K:CYS484 1.7 115.8 1.0
ND1 K:HIS487 2.3 115.8 1.0
SG K:CYS452 2.3 115.8 1.0
SG K:CYS484 2.3 115.8 1.0
CE1 K:HIS487 2.3 115.8 1.0
CA K:CYS452 2.8 115.8 1.0
CB K:CYS452 2.9 115.8 1.0
CA K:CYS484 3.0 115.8 1.0
N K:CYS452 3.3 115.8 1.0
O K:CYS484 3.3 115.8 1.0
O K:PRO451 3.6 115.8 1.0
C K:CYS484 3.6 115.8 1.0
NE2 K:HIS487 3.6 115.8 1.0
C K:PRO451 3.6 115.8 1.0
CG K:HIS487 3.7 115.8 1.0
C K:CYS452 4.1 115.8 1.0
N K:CYS484 4.2 115.8 1.0
CD2 K:HIS487 4.3 115.8 1.0
O K:SER450 4.3 115.8 1.0
N K:GLU453 4.6 115.8 1.0
CB K:HIS487 4.6 115.8 1.0
O K:VAL483 4.7 115.8 1.0
CA K:PRO451 4.8 115.8 1.0
C K:VAL483 4.8 115.8 1.0
N K:ARG485 4.9 115.8 1.0

Zinc binding site 8 out of 13 in 7eiz

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Zinc binding site 8 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn701

b:216.6
occ:1.00
NE2 E:HIS33 2.0 185.2 1.0
ND1 E:HIS39 2.0 186.8 1.0
CE1 E:HIS39 2.2 186.8 1.0
SG E:CYS19 2.3 185.2 1.0
SG E:CYS16 2.3 168.8 1.0
CG E:HIS39 2.8 186.8 1.0
CD2 E:HIS33 2.8 185.2 1.0
CE1 E:HIS33 3.0 185.2 1.0
NE2 E:HIS39 3.0 186.8 1.0
CD2 E:HIS39 3.3 186.8 1.0
CB E:CYS19 3.3 185.2 1.0
CB E:CYS16 3.6 168.8 1.0
N E:CYS19 3.7 185.2 1.0
CB E:HIS39 3.7 186.8 1.0
CB E:ALA110 3.9 206.9 1.0
CG E:HIS33 4.0 185.2 1.0
ND1 E:HIS33 4.0 185.2 1.0
CA E:CYS19 4.0 185.2 1.0
C E:ALA18 4.3 176.6 1.0
O E:ALA110 4.4 206.9 1.0
O E:CYS16 4.6 168.8 1.0
CB E:ALA18 4.7 176.6 1.0
O E:ALA18 4.7 176.6 1.0
CZ E:PHE106 4.9 195.1 1.0
CA E:ALA110 4.9 206.9 1.0
CA E:CYS16 4.9 168.8 1.0
CA E:ALA18 5.0 176.6 1.0
CA E:HIS39 5.0 186.8 1.0

Zinc binding site 9 out of 13 in 7eiz

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Zinc binding site 9 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn702

b:227.6
occ:1.00
SG E:CYS26 2.3 190.4 1.0
SG E:CYS8 2.3 199.0 1.0
SG E:CYS29 2.3 196.4 1.0
SG E:CYS5 2.3 179.0 1.0
CB E:CYS26 2.4 190.4 1.0
CB E:CYS8 2.5 199.0 1.0
N E:CYS26 2.8 190.4 1.0
CA E:CYS26 3.1 190.4 1.0
CB E:CYS29 3.2 196.4 1.0
CB E:CYS5 3.2 179.0 1.0
N E:CYS8 3.4 199.0 1.0
CA E:CYS8 3.6 199.0 1.0
C E:CYS26 3.9 190.4 1.0
O E:CYS26 3.9 190.4 1.0
C E:LEU25 4.0 175.9 1.0
C E:LEU7 4.1 202.2 1.0
OG E:SER10 4.1 180.6 1.0
N E:CYS29 4.3 196.4 1.0
CA E:CYS29 4.3 196.4 1.0
CB E:LEU7 4.3 202.2 1.0
C E:CYS8 4.5 199.0 1.0
CA E:LEU25 4.5 175.9 1.0
CA E:LEU7 4.6 202.2 1.0
CA E:CYS5 4.6 179.0 1.0
N E:LEU7 4.7 202.2 1.0
N E:GLY99 4.8 195.5 1.0
CA E:GLY99 4.8 195.5 1.0
O E:LEU7 4.8 202.2 1.0
N E:ASN9 4.9 187.3 1.0
O E:CYS5 4.9 179.0 1.0
C E:CYS5 5.0 179.0 1.0

Zinc binding site 10 out of 13 in 7eiz

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Zinc binding site 10 out of 13 in the Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars- Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn703

b:548.2
occ:1.00
ND1 E:HIS75 2.2 436.4 1.0
CB E:CYS55 2.2 428.5 1.0
SG E:CYS72 2.3 405.9 1.0
SG E:CYS55 2.3 428.5 1.0
SG E:CYS50 2.3 377.0 1.0
CE1 E:HIS75 2.8 436.4 1.0
OG E:SER74 2.9 438.9 1.0
CB E:ALA52 3.0 417.1 1.0
CB E:CYS72 3.1 405.9 1.0
CG E:HIS75 3.4 436.4 1.0
CA E:CYS55 3.7 428.5 1.0
N E:CYS72 3.8 405.9 1.0
CB E:HIS75 4.0 436.4 1.0
NE2 E:HIS75 4.0 436.4 1.0
O E:ALA52 4.0 417.1 1.0
CA E:CYS72 4.0 405.9 1.0
N E:HIS75 4.1 436.4 1.0
CB E:CYS50 4.1 377.0 1.0
CB E:SER74 4.3 438.9 1.0
N E:CYS55 4.3 428.5 1.0
CA E:ALA52 4.3 417.1 1.0
CD2 E:HIS75 4.3 436.4 1.0
C E:ALA52 4.4 417.1 1.0
C E:CYS55 4.5 428.5 1.0
N E:SER74 4.6 438.9 1.0
CA E:HIS75 4.7 436.4 1.0
O E:CYS50 4.8 377.0 1.0
N E:LYS73 4.8 404.5 1.0
C E:CYS72 4.8 405.9 1.0
CA E:SER74 4.8 438.9 1.0
C E:SER74 4.9 438.9 1.0
O E:PRO53 4.9 431.1 1.0
C E:TYR71 5.0 383.4 1.0
N E:ALA52 5.0 417.1 1.0

Reference:

L.Yan, Y.Yang, M.Li, Y.Zhang, L.Zheng, J.Ge, Y.C.Huang, Z.Liu, T.Wang, S.Gao, R.Zhang, Y.Y.Huang, L.W.Guddat, Y.Gao, Z.Rao, Z.Lou. Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars-Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading. Cell V. 184 3474 2021.
ISSN: ISSN 1097-4172
PubMed: 34143953
DOI: 10.1016/J.CELL.2021.05.033
Page generated: Fri Sep 24 17:05:37 2021

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