Zinc in PDB 7d4q: Structure of Human TRPC5 in Complex with Hc-070

The structure of Structure of Human TRPC5 in Complex with Hc-070 also contains other interesting chemical elements:

Calcium	(Ca)	4 atoms
Chlorine	(Cl)	8 atoms

The binding sites of Zinc atom in the Structure of Human TRPC5 in Complex with Hc-070 (pdb code 7d4q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Human TRPC5 in Complex with Hc-070, PDB code: 7d4q:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of Human TRPC5 in Complex with Hc-070


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human TRPC5 in Complex with Hc-070 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn804 b:208.6 occ:1.00 ND1 A:HIS172 2.1 166.3 1.0 SG A:CYS178 2.3 177.6 1.0 SG A:CYS181 2.3 186.6 1.0 SG A:CYS176 2.3 159.7 1.0 CE1 A:HIS172 3.0 158.7 1.0 CG A:HIS172 3.1 153.3 1.0 CB A:CYS181 3.3 166.4 1.0 CB A:CYS178 3.4 173.9 1.0 CB A:HIS172 3.4 147.7 1.0 CB A:CYS176 3.6 158.4 1.0 N A:CYS178 4.1 160.7 1.0 N A:CYS181 4.1 167.7 1.0 NE2 A:HIS172 4.1 152.6 1.0 CD2 A:HIS172 4.2 151.4 1.0 CA A:CYS178 4.3 166.6 1.0 CA A:CYS181 4.3 162.0 1.0 C A:CYS178 4.8 165.6 1.0 CA A:CYS176 4.8 160.7 1.0 C A:CYS176 4.8 166.7 1.0 O A:CYS178 4.8 164.8 1.0 CA A:HIS172 4.9 143.2 1.0 N A:ASN177 5.0 168.1 1.0

Zinc binding site 2 out of 4 in the Structure of Human TRPC5 in Complex with Hc-070


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human TRPC5 in Complex with Hc-070 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn804 b:208.6 occ:1.00 ND1 B:HIS172 2.1 166.3 1.0 SG B:CYS178 2.3 177.6 1.0 SG B:CYS181 2.3 186.6 1.0 SG B:CYS176 2.3 159.7 1.0 CE1 B:HIS172 3.0 158.7 1.0 CG B:HIS172 3.1 153.3 1.0 CB B:CYS181 3.3 166.4 1.0 CB B:CYS178 3.4 173.9 1.0 CB B:HIS172 3.4 147.7 1.0 CB B:CYS176 3.6 158.4 1.0 N B:CYS178 4.1 160.7 1.0 N B:CYS181 4.1 167.7 1.0 NE2 B:HIS172 4.1 152.6 1.0 CD2 B:HIS172 4.2 151.4 1.0 CA B:CYS178 4.3 166.6 1.0 CA B:CYS181 4.3 162.0 1.0 C B:CYS178 4.8 165.6 1.0 CA B:CYS176 4.8 160.7 1.0 C B:CYS176 4.8 166.7 1.0 O B:CYS178 4.8 164.8 1.0 CA B:HIS172 4.9 143.2 1.0 N B:ASN177 5.0 168.1 1.0

Zinc binding site 3 out of 4 in the Structure of Human TRPC5 in Complex with Hc-070


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Human TRPC5 in Complex with Hc-070 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn804 b:208.6 occ:1.00 ND1 C:HIS172 2.1 166.3 1.0 SG C:CYS178 2.3 177.6 1.0 SG C:CYS181 2.3 186.6 1.0 SG C:CYS176 2.3 159.7 1.0 CE1 C:HIS172 3.0 158.7 1.0 CG C:HIS172 3.1 153.3 1.0 CB C:CYS181 3.3 166.4 1.0 CB C:CYS178 3.4 173.9 1.0 CB C:HIS172 3.4 147.7 1.0 CB C:CYS176 3.6 158.4 1.0 N C:CYS178 4.1 160.7 1.0 N C:CYS181 4.1 167.7 1.0 NE2 C:HIS172 4.1 152.6 1.0 CD2 C:HIS172 4.2 151.4 1.0 CA C:CYS178 4.3 166.6 1.0 CA C:CYS181 4.3 162.0 1.0 C C:CYS178 4.8 165.6 1.0 CA C:CYS176 4.8 160.7 1.0 C C:CYS176 4.8 166.7 1.0 O C:CYS178 4.8 164.8 1.0 CA C:HIS172 4.9 143.2 1.0 N C:ASN177 5.0 168.1 1.0

Zinc binding site 4 out of 4 in the Structure of Human TRPC5 in Complex with Hc-070


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Human TRPC5 in Complex with Hc-070 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn804 b:208.6 occ:1.00 ND1 D:HIS172 2.1 166.3 1.0 SG D:CYS178 2.3 177.6 1.0 SG D:CYS181 2.3 186.6 1.0 SG D:CYS176 2.3 159.7 1.0 CE1 D:HIS172 3.0 158.7 1.0 CG D:HIS172 3.1 153.3 1.0 CB D:CYS181 3.3 166.4 1.0 CB D:CYS178 3.4 173.9 1.0 CB D:HIS172 3.4 147.7 1.0 CB D:CYS176 3.6 158.4 1.0 N D:CYS178 4.1 160.7 1.0 N D:CYS181 4.1 167.7 1.0 NE2 D:HIS172 4.1 152.6 1.0 CD2 D:HIS172 4.2 151.4 1.0 CA D:CYS178 4.3 166.6 1.0 CA D:CYS181 4.3 162.0 1.0 C D:CYS178 4.8 165.6 1.0 CA D:CYS176 4.8 160.7 1.0 C D:CYS176 4.8 166.7 1.0 O D:CYS178 4.9 164.8 1.0 CA D:HIS172 4.9 143.2 1.0 N D:ASN177 5.0 168.1 1.0

L.Chen, K.Song, M.Wei, W.Guo. Structure of Human TRPC5 in Complex with Hc-070 To Be Published.