Zinc in PDB 7bot: Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23

All present enzymatic activity of Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23:
2.3.1.286;

The structure of Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23, PDB code: 7bot was solved by N.Kudo, C.A.Olsen, Y.Minoru, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	35.83, 65.494, 114.889, 90, 90, 90
R / Rfree (%)	25.1 / 32

The binding sites of Zinc atom in the Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23 (pdb code 7bot). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23, PDB code: 7bot:

Zinc binding site 1 out of 1 in the Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SIRT2 in Complex with Myristoyl Thiourea Inhibitor, No.23 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:71.6 occ:1.00 SG A:CYS221 2.3 77.8 1.0 SG A:CYS200 2.5 70.1 1.0 SG A:CYS195 2.5 64.8 1.0 SG A:CYS224 2.6 70.1 1.0 CB A:CYS221 3.0 83.0 1.0 CB A:CYS195 3.2 63.0 1.0 CB A:CYS200 3.3 72.4 1.0 CB A:CYS224 3.3 86.2 1.0 N A:CYS224 3.7 95.5 1.0 CB A:HIS202 3.9 72.3 1.0 CA A:CYS224 4.0 86.0 1.0 N A:HIS202 4.1 74.4 1.0 CB A:SER197 4.3 59.1 1.0 N A:ARG201 4.4 80.5 1.0 CA A:CYS221 4.5 83.7 1.0 CB A:ASP223 4.6 95.5 1.0 CA A:CYS200 4.6 74.3 1.0 C A:ASP223 4.7 98.5 1.0 CA A:HIS202 4.7 73.3 1.0 CA A:CYS195 4.7 60.9 1.0 C A:CYS200 4.8 77.2 1.0 OG A:SER197 4.8 60.5 1.0 CG A:HIS202 4.9 75.7 1.0 N A:ASP223 4.9 96.5 1.0 CA A:ASP223 5.0 96.1 1.0

A.L.Nielsen, C.A.Olsen. Selective Inhibitors of SIRT2 Regulate Perinuclear Alpha-Tubulin Acetylation, Migration, and Invasion of Breast Cancer Cells To Be Published.