Zinc in PDB 6xty: Cryoem Structure of Human Cmg Bound to and-1 (Cmga)

All present enzymatic activity of Cryoem Structure of Human Cmg Bound to and-1 (Cmga):
3.6.4.12;

The binding sites of Zinc atom in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga) (pdb code 6xty). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga), PDB code: 6xty:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Human Cmg Bound to and-1 (Cmga) within 5.0Å range: probe atom residue distance (Å) B Occ 2:Zn1000 b:0.9 occ:1.00 SG 2:CYS332 2.2 0.9 1.0 SG 2:CYS352 2.2 0.3 1.0 SG 2:CYS355 2.2 0.8 1.0 SG 2:CYS329 2.3 0.4 1.0 CB 2:CYS329 2.8 0.4 1.0 CB 2:CYS352 3.1 0.3 1.0 CB 2:CYS332 3.1 0.9 1.0 CB 2:CYS355 3.9 0.8 1.0 N 2:CYS332 4.0 0.9 1.0 OG 2:SER357 4.1 0.0 1.0 N 2:CYS355 4.1 0.8 1.0 CA 2:CYS332 4.2 0.9 1.0 CA 2:CYS329 4.3 0.4 1.0 CB 2:SER357 4.3 0.0 1.0 CA 2:CYS355 4.5 0.8 1.0 CA 2:CYS352 4.6 0.3 1.0 C 2:LYS331 4.7 0.3 1.0 CB 2:GLU354 4.8 0.4 1.0 N 2:LYS331 4.8 0.3 1.0 C 2:CYS329 4.8 0.4 1.0 C 2:GLU354 4.9 0.4 1.0 C 2:CYS355 5.0 0.8 1.0 N 2:SER357 5.0 0.0 1.0

Zinc binding site 2 out of 5 in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryoem Structure of Human Cmg Bound to and-1 (Cmga) within 5.0Å range: probe atom residue distance (Å) B Occ 4:Zn1000 b:0.7 occ:1.00 SG 4:CYS306 2.1 0.3 1.0 SG 4:CYS328 2.1 0.8 1.0 SG 4:CYS309 2.2 0.7 1.0 SG 4:CYS331 2.3 0.3 1.0 CB 4:CYS328 2.5 0.8 1.0 CB 4:CYS306 2.8 0.3 1.0 CB 4:CYS309 3.1 0.7 1.0 N 4:CYS309 3.2 0.7 1.0 OG 4:SER336 3.4 0.6 1.0 CA 4:CYS309 3.7 0.7 1.0 CB 4:CYS331 3.8 0.3 1.0 CA 4:CYS328 3.9 0.8 1.0 CB 4:VAL308 4.2 0.4 1.0 CA 4:CYS306 4.2 0.3 1.0 C 4:VAL308 4.3 0.4 1.0 N 4:VAL308 4.4 0.4 1.0 N 4:CYS331 4.5 0.3 1.0 CA 4:VAL308 4.5 0.4 1.0 SD 4:MET337 4.6 0.7 1.0 C 4:CYS309 4.6 0.7 1.0 CB 4:SER336 4.6 0.6 1.0 CA 4:CYS331 4.7 0.3 1.0 N 4:ALA310 4.7 0.8 1.0 N 4:CYS328 4.7 0.8 1.0 N 4:HIS332 4.8 0.8 1.0 C 4:CYS306 4.8 0.3 1.0 C 4:CYS328 4.8 0.8 1.0 CG1 4:VAL308 4.9 0.4 1.0 N 4:GLN307 5.0 0.6 1.0

Zinc binding site 3 out of 5 in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryoem Structure of Human Cmg Bound to and-1 (Cmga) within 5.0Å range: probe atom residue distance (Å) B Occ 5:Zn1000 b:0.1 occ:1.00 SG 5:CYS175 2.1 0.7 1.0 SG 5:CYS197 2.2 0.7 1.0 SG 5:CYS207 2.3 0.3 1.0 SG 5:CYS172 2.3 0.1 1.0 CB 5:CYS175 3.1 0.7 1.0 CB 5:CYS172 3.4 0.1 1.0 CB 5:CYS207 3.4 0.3 1.0 CB 5:CYS197 3.5 0.7 1.0 N 5:CYS175 3.6 0.7 1.0 OG 5:SER174 3.8 0.2 1.0 CA 5:CYS175 3.9 0.7 1.0 C 5:CYS175 4.4 0.7 1.0 N 5:ARG176 4.5 0.3 1.0 CB 5:ASN177 4.7 0.8 1.0 N 5:ASN177 4.7 0.8 1.0 C 5:SER174 4.7 0.2 1.0 CA 5:CYS172 4.8 0.1 1.0 CA 5:CYS207 4.8 0.3 1.0 CA 5:CYS197 4.8 0.7 1.0 N 5:SER174 4.8 0.2 1.0 CG 5:PRO211 4.9 0.8 1.0 CB 5:PRO211 4.9 0.8 1.0 CB 5:SER174 5.0 0.2 1.0

Zinc binding site 4 out of 5 in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryoem Structure of Human Cmg Bound to and-1 (Cmga) within 5.0Å range: probe atom residue distance (Å) B Occ 6:Zn1000 b:0.5 occ:1.00 SG 6:CYS185 2.3 0.1 1.0 SG 6:CYS158 2.3 0.3 1.0 SG 6:CYS161 2.4 0.2 1.0 SG 6:CYS180 2.4 0.2 1.0 CB 6:CYS185 3.0 0.1 1.0 CB 6:CYS180 3.2 0.2 1.0 OD1 6:ASP160 3.3 0.1 1.0 CB 6:CYS161 3.4 0.2 1.0 CA 6:CYS185 3.8 0.1 1.0 CB 6:CYS158 3.8 0.3 1.0 OG1 6:THR163 4.0 0.2 1.0 CE1 6:PHE191 4.2 0.1 1.0 N 6:CYS161 4.3 0.2 1.0 CB 6:ASN182 4.3 0.1 1.0 CA 6:CYS161 4.5 0.2 1.0 CG 6:ASP160 4.5 0.1 1.0 CA 6:CYS180 4.7 0.2 1.0 O 6:VAL184 4.7 0.6 1.0 N 6:CYS185 4.8 0.1 1.0 ND2 6:ASN182 4.8 0.1 1.0 C 6:CYS185 4.8 0.1 1.0 CZ 6:PHE191 4.8 0.1 1.0 OD2 6:ASP160 4.9 0.1 1.0 OD1 6:ASN187 5.0 0.5 1.0

Zinc binding site 5 out of 5 in the Cryoem Structure of Human Cmg Bound to and-1 (Cmga)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Cryoem Structure of Human Cmg Bound to and-1 (Cmga) within 5.0Å range: probe atom residue distance (Å) B Occ 7:Zn1000 b:0.9 occ:1.00 SG 7:CYS184 2.2 0.8 1.0 SG 7:CYS206 2.3 0.2 1.0 SG 7:CYS187 2.3 0.0 1.0 SG 7:CYS211 2.4 0.5 1.0 CB 7:CYS184 2.9 0.8 1.0 CB 7:CYS211 3.0 0.5 1.0 CB 7:CYS187 3.0 0.0 1.0 CB 7:CYS206 3.6 0.2 1.0 N 7:CYS187 4.0 0.0 1.0 CA 7:CYS187 4.1 0.0 1.0 OG 7:SER208 4.1 0.4 1.0 CA 7:CYS184 4.4 0.8 1.0 CA 7:CYS211 4.5 0.5 1.0 O 7:CYS184 4.8 0.8 1.0 C 7:CYS184 4.9 0.8 1.0 C 7:CYS187 4.9 0.0 1.0 CA 7:CYS206 5.0 0.2 1.0

N.J.Rzechorzek, S.W.Hardwick, V.A.Jatikusumo, D.Y.Chirgadze, L.Pellegrini. Cryoem Structures of Human Cmg - Atpgammas - Dna and Cmg - and-1 Complexes Nucleic Acids Res. 2020.
ISSN: ESSN 1362-4962
DOI: 10.1093/NAR/GKAA429