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Atomistry » Zinc » PDB 6wbz-6woy » 6wbz » |
Zinc in PDB 6wbz: Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic GroupEnzymatic activity of Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group
All present enzymatic activity of Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group:
3.5.1.98; Protein crystallography data
The structure of Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group, PDB code: 6wbz
was solved by
D.J.Klein,
W.Yu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6wbz:
The structure of Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group
(pdb code 6wbz). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group, PDB code: 6wbz: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 6wbzGo back to Zinc Binding Sites List in 6wbz
Zinc binding site 1 out
of 3 in the Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 6wbzGo back to Zinc Binding Sites List in 6wbz
Zinc binding site 2 out
of 3 in the Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 6wbzGo back to Zinc Binding Sites List in 6wbz
Zinc binding site 3 out
of 3 in the Structure of Human HDAC2 in Complex with An Ethyl Ketone Inhibitor Containing A Spiro-Bicyclic Group
Mono view Stereo pair view
Reference:
W.Yu,
J.Liu,
Y.Yu,
V.Zhang,
D.Clausen,
J.Kelly,
S.Wolkenberg,
D.Beshore,
J.L.Duffy,
C.C.Chang,
R.W.Myers,
D.J.Klein,
J.Fells,
K.Holloway,
J.Wu,
G.Wu,
B.J.Howell,
R.J.O.Barnard,
J.Kozlowski.
Discovery of Ethyl Ketone-Based Hdacs 1, 2, and 3 Selective Inhibitors For Hiv Latency Reactivation. Bioorg.Med.Chem.Lett. 27197 2020.
Page generated: Tue Oct 29 09:18:53 2024
ISSN: ESSN 1464-3405 PubMed: 32331932 DOI: 10.1016/J.BMCL.2020.127197 |
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