Zinc in PDB 6t5y: Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107)

All present enzymatic activity of Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107):
3.5.2.6;

The structure of Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107), PDB code: 6t5y was solved by P.A.Lang, T.M.Leissing, C.J.Schofield, J.Brem, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	61.61 / 1.30
Space group	P 43 3 2
Cell size a, b, c (Å), α, β, γ (°)	137.760, 137.760, 137.760, 90.00, 90.00, 90.00
R / Rfree (%)	13.2 / 14.9

The structure of Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107) also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107) (pdb code 6t5y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107), PDB code: 6t5y:

Zinc binding site 1 out of 1 in the Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ampc From E.Coli with Zidebactam (Wck 5107) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn603 b:11.8 occ:0.33 NE2 A:HIS13 2.0 10.6 1.0 CL A:CL604 2.3 15.2 0.3 CD2 A:HIS13 3.0 10.4 1.0 CE1 A:HIS13 3.0 11.1 1.0 O A:HOH1038 4.1 25.7 0.3 ND1 A:HIS13 4.1 11.2 1.0 CG A:HIS13 4.2 10.5 1.0

P.A.Lang, T.M.Leissing, M.G.P.Page, C.J.Schofield, J.Brem. Structural Investigations of the Inhibition of Escherichia Coli Ampc Beta-Lactamase By Diazabicyclooctanes. Antimicrob.Agents Chemother. 2020.
ISSN: ESSN 1098-6596
PubMed: 33199391
DOI: 10.1128/AAC.02073-20