Zinc in PDB 6hzx: Protein-Aromatic Foldamer Complex Crystal Structure

Enzymatic activity of Protein-Aromatic Foldamer Complex Crystal Structure

All present enzymatic activity of Protein-Aromatic Foldamer Complex Crystal Structure:
4.2.1.1;

Protein crystallography data

The structure of Protein-Aromatic Foldamer Complex Crystal Structure, PDB code: 6hzx was solved by S.Post, B.Langlois D'estaintot, L.Fischer, T.Granier, I.Huc, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.73 / 2.91
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 82.640, 82.640, 106.390, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 21.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Protein-Aromatic Foldamer Complex Crystal Structure (pdb code 6hzx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Protein-Aromatic Foldamer Complex Crystal Structure, PDB code: 6hzx:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6hzx

Go back to Zinc Binding Sites List in 6hzx
Zinc binding site 1 out of 2 in the Protein-Aromatic Foldamer Complex Crystal Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Protein-Aromatic Foldamer Complex Crystal Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:65.2
occ:1.00
NE2 A:HIS94 2.0 64.1 1.0
NE2 A:HIS96 2.0 70.3 1.0
ND1 A:HIS119 2.1 66.4 1.0
N26 A:6H0302 2.2 69.4 1.0
CE1 A:HIS94 3.0 64.1 1.0
CD2 A:HIS94 3.0 64.2 1.0
CD2 A:HIS96 3.0 71.3 1.0
CE1 A:HIS119 3.0 68.7 1.0
O27 A:6H0302 3.0 67.6 1.0
CE1 A:HIS96 3.0 70.5 1.0
S24 A:6H0302 3.1 68.5 1.0
CG A:HIS119 3.2 66.1 1.0
CB A:HIS119 3.6 65.3 1.0
OG1 A:THR198 3.8 71.0 1.0
OE1 A:GLU106 3.9 83.6 1.0
ND1 A:HIS94 4.1 63.7 1.0
CG A:HIS94 4.1 63.5 1.0
C21 A:6H0302 4.1 68.8 1.0
CG A:HIS96 4.1 72.0 1.0
ND1 A:HIS96 4.1 71.4 1.0
NE2 A:HIS119 4.2 70.7 1.0
CD2 A:HIS119 4.3 68.8 1.0
O25 A:6H0302 4.3 69.4 1.0
C20 A:6H0302 4.6 68.1 1.0
C3 A:GOL322 4.7 72.6 1.0
CD A:GLU106 4.9 83.7 1.0
C22 A:6H0302 5.0 69.4 1.0

Zinc binding site 2 out of 2 in 6hzx

Go back to Zinc Binding Sites List in 6hzx
Zinc binding site 2 out of 2 in the Protein-Aromatic Foldamer Complex Crystal Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Protein-Aromatic Foldamer Complex Crystal Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:69.6
occ:1.00
NE2 B:HIS94 1.9 67.5 1.0
NE2 B:HIS96 2.1 70.6 1.0
ND1 B:HIS119 2.1 70.9 1.0
N26 B:6H0302 2.2 75.2 1.0
O27 B:6H0302 2.8 74.6 1.0
CE1 B:HIS94 2.9 67.2 1.0
CD2 B:HIS94 2.9 68.8 1.0
CE1 B:HIS96 3.0 70.9 1.0
S24 B:6H0302 3.0 74.2 1.0
CE1 B:HIS119 3.1 71.7 1.0
CD2 B:HIS96 3.1 72.1 1.0
CG B:HIS119 3.2 71.7 1.0
CB B:HIS119 3.5 71.1 1.0
OG1 B:THR198 3.8 70.0 1.0
ND1 B:HIS94 4.0 68.1 1.0
OE1 B:GLU106 4.0 70.2 1.0
CG B:HIS94 4.0 69.5 1.0
C21 B:6H0302 4.0 75.2 1.0
ND1 B:HIS96 4.1 72.7 1.0
O25 B:6H0302 4.2 73.4 1.0
CG B:HIS96 4.2 73.0 1.0
NE2 B:HIS119 4.2 72.5 1.0
CD2 B:HIS119 4.3 73.1 1.0
C3 B:GOL322 4.4 82.9 1.0
C22 B:6H0302 4.7 76.1 1.0
C20 B:6H0302 4.8 75.9 1.0
CD B:GLU106 5.0 71.4 1.0
CA B:HIS119 5.0 72.2 1.0

Reference:

P.S.Reddy, B.Langlois D'estaintot, T.Granier, C.D.Mackereth, L.Fischer, I.Huc. Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas. Chemistry V. 25 11042 2019.
ISSN: ISSN 0947-6539
PubMed: 31257622
DOI: 10.1002/CHEM.201902942
Page generated: Wed Dec 16 11:59:12 2020

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