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Zinc in PDB 6ceh: Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology

Enzymatic activity of Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology

All present enzymatic activity of Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology:
4.2.1.1;

Protein crystallography data

The structure of Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology, PDB code: 6ceh was solved by T.S.Peat, A.Angeli, L.Di Cesare Mannelli, E.Trallori, C.Ghelardini, F.Carta, C.T.Supuran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.50 / 1.43
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.452, 41.485, 72.455, 90.00, 104.49, 90.00
R / Rfree (%) 15.2 / 20.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology (pdb code 6ceh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology, PDB code: 6ceh:

Zinc binding site 1 out of 1 in 6ceh

Go back to Zinc Binding Sites List in 6ceh
Zinc binding site 1 out of 1 in the Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Design, Synthesis, X-Ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:4.8
occ:1.00
 N11 A:EZ1302 2.0 4.7 1.0
NE2 A:HIS96 2.0 5.1 1.0
ND1 A:HIS119 2.0 4.4 1.0
NE2 A:HIS94 2.0 4.4 1.0
CE1 A:HIS119 2.9 4.9 1.0
CD2 A:HIS94 3.0 5.0 1.0
CD2 A:HIS96 3.0 5.0 1.0
CE1 A:HIS96 3.0 5.3 1.0
S9 A:EZ1302 3.1 5.5 1.0
CE1 A:HIS94 3.1 5.2 1.0
O12 A:EZ1302 3.1 5.7 1.0
CG A:HIS119 3.2 4.5 1.0
CB A:HIS119 3.6 4.6 1.0
OG1 A:THR199 3.9 4.5 1.0
OE1 A:GLU106 4.0 6.1 1.0
NE2 A:HIS119 4.1 4.4 1.0
C8 A:EZ1302 4.1 5.6 1.0
O10 A:EZ1302 4.2 6.2 1.0
CG A:HIS94 4.2 4.7 1.0
ND1 A:HIS96 4.2 6.6 1.0
ND1 A:HIS94 4.2 4.9 1.0
CG A:HIS96 4.2 6.1 1.0
CD2 A:HIS119 4.2 3.9 1.0
C3 A:GOL304 4.6 11.4 1.0
C13 A:EZ1302 4.7 6.3 1.0
CD A:GLU106 4.9 6.0 1.0
C7 A:EZ1302 4.9 6.9 1.0

Reference:

A.Angeli, L.Di Cesare Mannelli, E.Trallori, T.S.Peat, C.Ghelardini, F.Carta, C.T.Supuran. Design, Synthesis, and X-Ray of Selenides As New Class of Agents For Prevention of Diabetic Cerebrovascular Pathology. Acs Med Chem Lett V. 9 462 2018.
ISSN: ISSN 1948-5875
PubMed: 29795760
DOI: 10.1021/ACSMEDCHEMLETT.8B00076
Page generated: Mon Oct 28 18:49:43 2024

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