Zinc in PDB 5ynq: Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG

The structure of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG, PDB code: 5ynq was solved by S.M.Wei, L.Yang, Z.H.Ke, D.Y.Guo, C.P.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.35 / 1.96
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.874, 70.101, 118.937, 90.00, 90.00, 90.00
R / Rfree (%)	18.6 / 21.7

The binding sites of Zinc atom in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG (pdb code 5ynq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG, PDB code: 5ynq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:44.7 occ:1.00 NE2 B:HIS83 2.1 67.9 1.0 SG B:CYS90 2.3 51.9 1.0 SG B:CYS74 2.3 52.2 1.0 SG B:CYS77 2.4 50.5 1.0 CD2 B:HIS83 2.9 62.9 1.0 CB B:CYS90 3.2 46.8 1.0 CB B:CYS74 3.2 51.5 1.0 CE1 B:HIS83 3.3 64.8 1.0 CB B:CYS77 3.4 46.5 1.0 N B:CYS77 3.5 49.3 1.0 CA B:CYS77 3.9 50.8 1.0 CG B:HIS83 4.1 61.4 1.0 ND1 B:HIS83 4.3 62.9 1.0 C B:TYR76 4.4 51.4 1.0 CA B:CYS90 4.4 52.5 1.0 CB B:TYR76 4.5 50.5 1.0 CA B:CYS74 4.6 52.0 1.0 CB B:LYS93 4.6 46.8 1.0 O B:HOH316 4.8 52.9 1.0 CA B:TYR76 4.9 49.0 1.0 N B:LYS93 4.9 44.2 1.0 C B:CYS74 5.0 50.0 1.0 O B:CYS74 5.0 49.0 1.0 N B:TYR76 5.0 48.4 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sah and M7GPPPG within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:96.2 occ:1.00 SG B:CYS117 2.3 93.3 1.0 SG B:CYS128 2.3 82.6 1.0 SG B:CYS130 2.3 0.7 1.0 SG B:CYS120 2.3 85.3 1.0 CB B:CYS120 3.0 85.9 1.0 CB B:CYS117 3.2 87.5 1.0 CB B:CYS130 3.2 0.5 1.0 CB B:CYS128 3.5 79.3 1.0 CG1 B:VAL119 3.6 0.1 1.0 N B:CYS120 3.8 88.5 1.0 N B:CYS130 3.9 0.3 1.0 CA B:CYS120 3.9 86.2 1.0 CA B:CYS128 4.1 83.8 1.0 CA B:CYS130 4.2 0.5 1.0 N B:ASN129 4.3 91.3 1.0 C B:CYS128 4.4 88.0 1.0 CA B:CYS117 4.7 85.3 1.0 C B:CYS120 4.7 86.8 1.0 C B:VAL119 4.8 92.8 1.0 C B:ASN129 4.9 0.4 1.0 CB B:VAL119 5.0 0.2 1.0

S.M.Wei, L.Yang, Z.H.Ke, Q.Y.Liu, Z.Z.Yang, Y.Chen, D.Y.Guo, C.P.Fan. Structural Insights Into the Molecular Mechanism of Mers Coronavirus Rna Ribose 2'-O-Methylation By NSP16/NSP10 Protein Complex To Be Published.