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Zinc in PDB 5gk9: Crystal Structure of Human HBO1 in Complex with BRPF2

Enzymatic activity of Crystal Structure of Human HBO1 in Complex with BRPF2

All present enzymatic activity of Crystal Structure of Human HBO1 in Complex with BRPF2:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Human HBO1 in Complex with BRPF2, PDB code: 5gk9 was solved by Y.Tao, J.Zhu, S.Xu, J.Ding, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.40
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 126.470, 39.321, 87.666, 90.00, 122.10, 90.00
R / Rfree (%) 23.3 / 26

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human HBO1 in Complex with BRPF2 (pdb code 5gk9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human HBO1 in Complex with BRPF2, PDB code: 5gk9:

Zinc binding site 1 out of 1 in 5gk9

Go back to Zinc Binding Sites List in 5gk9
Zinc binding site 1 out of 1 in the Crystal Structure of Human HBO1 in Complex with BRPF2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human HBO1 in Complex with BRPF2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:40.1
occ:1.00
O A:HOH820 2.0 38.2 1.0
CE1 A:HIS384 2.2 48.5 1.0
SG A:CYS368 2.4 35.4 1.0
SG A:CYS388 2.4 44.4 1.0
SG A:CYS371 2.4 42.9 1.0
NE2 A:HIS384 3.1 52.4 1.0
ND1 A:HIS384 3.2 54.7 1.0
CB A:CYS368 3.3 32.2 1.0
CB A:CYS371 3.3 40.0 1.0
CB A:CYS388 3.3 51.3 1.0
N A:CYS371 3.8 34.2 1.0
CA A:CYS371 4.1 35.3 1.0
CD2 A:HIS384 4.3 55.7 1.0
CG A:HIS384 4.4 53.8 1.0
CA A:CYS368 4.7 34.8 1.0
CA A:CYS388 4.7 55.4 1.0
C A:CYS371 4.8 35.4 1.0
N A:LEU372 4.9 34.9 1.0
C A:PHE370 4.9 35.0 1.0

Reference:

Y.Tao, C.Zhong, J.Zhu, S.Xu, J.Ding. Structural and Mechanistic Insights Into Regulation of HBO1 Histone Acetyltransferase Activity By BRPF2. Nucleic Acids Res. V. 45 5707 2017.
ISSN: ESSN 1362-4962
PubMed: 28334966
DOI: 10.1093/NAR/GKX142
Page generated: Wed Dec 16 06:19:31 2020

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