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Atomistry » Zinc » PDB 5fvu-5fz5 » 5fvv | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5fvu-5fz5 » 5fvv » |
Zinc in PDB 5fvv: Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-AmineEnzymatic activity of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
All present enzymatic activity of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 5fvv
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5fvv:
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
(pdb code 5fvv). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 5fvv: Zinc binding site 1 out of 1 in 5fvvGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
![]() Mono view ![]() Stereo pair view
Reference:
H.Wang,
Y.Qin,
H.Li,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition By Optimization of the 2-Aminopyridine-Based Scaffold with A Pyridine Linker. J.Med.Chem. V. 59 4913 2016.
Page generated: Wed Dec 16 06:16:52 2020
ISSN: ISSN 0022-2623 PubMed: 27050842 DOI: 10.1021/ACS.JMEDCHEM.6B00273 |
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