Zinc in PDB 5brm: Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
Enzymatic activity of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
All present enzymatic activity of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling:
2.7.11.1;
Protein crystallography data
The structure of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling, PDB code: 5brm
was solved by
X.Luo,
L.Ni,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
39.30 /
2.65
|
|
Space group
|
P 31 2 1
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
142.188,
142.188,
135.981,
90.00,
90.00,
120.00
|
|
R / Rfree (%)
|
24.4 /
26.8
|
Zinc Binding Sites:
The binding sites of Zinc atom in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
(pdb code 5brm). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the
Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling, PDB code: 5brm:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
Zinc binding site 1 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 1 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn301
b:14.0
occ:1.00
|
NE2
|
A:HIS161
|
1.9
|
15.2
|
1.0
|
|
NE2
|
A:HIS166
|
2.0
|
13.8
|
1.0
|
|
SG
|
A:CYS84
|
2.3
|
16.8
|
1.0
|
|
SG
|
A:CYS79
|
2.4
|
15.5
|
1.0
|
|
CE1
|
A:HIS161
|
2.7
|
14.8
|
1.0
|
|
HE1
|
A:HIS161
|
2.8
|
17.7
|
1.0
|
|
CE1
|
A:HIS166
|
2.9
|
13.9
|
1.0
|
|
CD2
|
A:HIS161
|
3.0
|
14.3
|
1.0
|
|
HE1
|
A:HIS166
|
3.1
|
16.7
|
1.0
|
|
CD2
|
A:HIS166
|
3.1
|
13.7
|
1.0
|
|
HA
|
A:CYS79
|
3.3
|
19.1
|
1.0
|
|
HD2
|
A:HIS166
|
3.3
|
16.4
|
1.0
|
|
HD2
|
A:HIS161
|
3.3
|
17.1
|
1.0
|
|
CB
|
A:CYS84
|
3.3
|
17.5
|
1.0
|
|
HB2
|
A:CYS79
|
3.3
|
18.4
|
1.0
|
|
HB2
|
A:CYS84
|
3.4
|
21.0
|
1.0
|
|
CB
|
A:CYS79
|
3.4
|
15.3
|
1.0
|
|
HB3
|
A:CYS84
|
3.4
|
21.0
|
1.0
|
|
HB3
|
A:ALA111
|
3.5
|
16.8
|
1.0
|
|
HB2
|
A:GLN165
|
3.8
|
37.0
|
1.0
|
|
HB1
|
A:ALA111
|
3.8
|
16.8
|
1.0
|
|
HB3
|
A:GLN165
|
3.8
|
37.0
|
1.0
|
|
CA
|
A:CYS79
|
3.9
|
16.0
|
1.0
|
|
ND1
|
A:HIS161
|
3.9
|
14.4
|
1.0
|
|
HG
|
A:SER83
|
4.0
|
37.2
|
1.0
|
|
CG
|
A:HIS161
|
4.0
|
14.3
|
1.0
|
|
CB
|
A:ALA111
|
4.1
|
14.0
|
1.0
|
|
ND1
|
A:HIS166
|
4.1
|
13.8
|
1.0
|
|
HG3
|
A:GLN165
|
4.2
|
40.8
|
1.0
|
|
CG
|
A:HIS166
|
4.2
|
13.7
|
1.0
|
|
HH
|
A:TYR72
|
4.2
|
17.8
|
1.0
|
|
CB
|
A:GLN165
|
4.2
|
30.8
|
1.0
|
|
HB3
|
A:CYS79
|
4.3
|
18.4
|
1.0
|
|
HB2
|
A:ALA111
|
4.3
|
16.8
|
1.0
|
|
HD3
|
A:PRO112
|
4.3
|
24.4
|
1.0
|
|
HE1
|
A:TYR72
|
4.5
|
16.8
|
1.0
|
|
HD1
|
A:HIS161
|
4.6
|
17.3
|
1.0
|
|
OG
|
A:SER83
|
4.7
|
31.0
|
1.0
|
|
H
|
A:THR80
|
4.7
|
21.5
|
1.0
|
|
C
|
A:CYS79
|
4.7
|
16.6
|
1.0
|
|
CA
|
A:CYS84
|
4.7
|
18.6
|
1.0
|
|
CG
|
A:GLN165
|
4.8
|
34.0
|
1.0
|
|
HD1
|
A:HIS166
|
4.8
|
16.6
|
1.0
|
|
HD13
|
A:ILE75
|
4.9
|
21.2
|
1.0
|
|
N
|
A:THR80
|
5.0
|
17.9
|
1.0
|
|
OH
|
A:TYR72
|
5.0
|
14.9
|
1.0
|
|
Zinc binding site 2 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 2 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn301
b:14.8
occ:1.00
|
NE2
|
B:HIS166
|
1.9
|
15.3
|
1.0
|
|
NE2
|
B:HIS161
|
2.0
|
23.9
|
1.0
|
|
SG
|
B:CYS84
|
2.3
|
24.0
|
1.0
|
|
SG
|
B:CYS79
|
2.3
|
20.4
|
1.0
|
|
CE1
|
B:HIS161
|
2.7
|
25.8
|
1.0
|
|
CE1
|
B:HIS166
|
2.8
|
15.4
|
1.0
|
|
HE1
|
B:HIS161
|
2.8
|
31.0
|
1.0
|
|
HE1
|
B:HIS166
|
2.9
|
18.5
|
1.0
|
|
CD2
|
B:HIS166
|
3.1
|
15.2
|
1.0
|
|
CD2
|
B:HIS161
|
3.1
|
24.0
|
1.0
|
|
HB2
|
B:CYS79
|
3.3
|
24.1
|
1.0
|
|
HA
|
B:CYS79
|
3.3
|
25.3
|
1.0
|
|
CB
|
B:CYS79
|
3.3
|
20.1
|
1.0
|
|
HD2
|
B:HIS166
|
3.4
|
18.2
|
1.0
|
|
CB
|
B:CYS84
|
3.4
|
24.5
|
1.0
|
|
HB3
|
B:CYS84
|
3.4
|
29.4
|
1.0
|
|
HB2
|
B:CYS84
|
3.4
|
29.4
|
1.0
|
|
HB3
|
B:ALA111
|
3.4
|
30.8
|
1.0
|
|
HD2
|
B:HIS161
|
3.5
|
28.8
|
1.0
|
|
HB1
|
B:ALA111
|
3.7
|
30.8
|
1.0
|
|
CA
|
B:CYS79
|
3.9
|
21.1
|
1.0
|
|
ND1
|
B:HIS161
|
3.9
|
22.8
|
1.0
|
|
HB2
|
B:GLN165
|
3.9
|
44.7
|
1.0
|
|
ND1
|
B:HIS166
|
4.0
|
15.3
|
1.0
|
|
CB
|
B:ALA111
|
4.0
|
25.7
|
1.0
|
|
HB3
|
B:GLN165
|
4.0
|
44.7
|
1.0
|
|
CG
|
B:HIS166
|
4.1
|
15.2
|
1.0
|
|
HG
|
B:SER83
|
4.1
|
38.5
|
1.0
|
|
CG
|
B:HIS161
|
4.1
|
23.0
|
1.0
|
|
HB3
|
B:CYS79
|
4.2
|
24.1
|
1.0
|
|
HH
|
B:TYR72
|
4.2
|
30.5
|
1.0
|
|
HD3
|
B:PRO112
|
4.2
|
31.6
|
1.0
|
|
HB2
|
B:ALA111
|
4.3
|
30.8
|
1.0
|
|
HG3
|
B:GLN165
|
4.4
|
47.3
|
1.0
|
|
CB
|
B:GLN165
|
4.4
|
37.3
|
1.0
|
|
HE1
|
B:TYR72
|
4.5
|
28.7
|
1.0
|
|
HD1
|
B:HIS161
|
4.6
|
27.3
|
1.0
|
|
C
|
B:CYS79
|
4.7
|
24.2
|
1.0
|
|
HD1
|
B:HIS166
|
4.7
|
18.4
|
1.0
|
|
H
|
B:THR80
|
4.7
|
29.3
|
1.0
|
|
CA
|
B:CYS84
|
4.8
|
26.0
|
1.0
|
|
OG
|
B:SER83
|
4.8
|
32.1
|
1.0
|
|
HG3
|
B:PRO112
|
4.9
|
31.9
|
1.0
|
|
CG
|
B:GLN165
|
5.0
|
39.4
|
1.0
|
|
Zinc binding site 3 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 3 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn301
b:49.7
occ:1.00
|
NE2
|
C:HIS166
|
1.9
|
41.6
|
1.0
|
|
NE2
|
C:HIS161
|
2.1
|
48.1
|
1.0
|
|
SG
|
C:CYS84
|
2.2
|
57.7
|
1.0
|
|
SG
|
C:CYS79
|
2.4
|
57.4
|
1.0
|
|
HB2
|
C:CYS79
|
2.8
|
62.8
|
1.0
|
|
CE1
|
C:HIS166
|
2.9
|
43.4
|
1.0
|
|
CD2
|
C:HIS166
|
2.9
|
39.7
|
1.0
|
|
HA
|
C:CYS79
|
3.0
|
63.6
|
1.0
|
|
CE1
|
C:HIS161
|
3.0
|
51.7
|
1.0
|
|
CB
|
C:CYS79
|
3.0
|
52.3
|
1.0
|
|
HE1
|
C:HIS166
|
3.1
|
52.0
|
1.0
|
|
HE1
|
C:HIS161
|
3.1
|
62.0
|
1.0
|
|
HD2
|
C:HIS166
|
3.1
|
47.7
|
1.0
|
|
CD2
|
C:HIS161
|
3.2
|
47.0
|
1.0
|
|
HB2
|
C:CYS84
|
3.3
|
69.8
|
1.0
|
|
CB
|
C:CYS84
|
3.3
|
58.2
|
1.0
|
|
HB3
|
C:CYS84
|
3.4
|
69.8
|
1.0
|
|
HD2
|
C:HIS161
|
3.4
|
56.4
|
1.0
|
|
CA
|
C:CYS79
|
3.5
|
53.0
|
1.0
|
|
HB3
|
C:ALA111
|
3.7
|
78.9
|
1.0
|
|
HB3
|
C:CYS79
|
3.9
|
62.8
|
1.0
|
|
ND1
|
C:HIS166
|
4.0
|
42.7
|
1.0
|
|
CG
|
C:HIS166
|
4.0
|
40.4
|
1.0
|
|
HB1
|
C:ALA111
|
4.1
|
78.9
|
1.0
|
|
ND1
|
C:HIS161
|
4.1
|
47.8
|
1.0
|
|
HB2
|
C:GLN165
|
4.2
|
84.5
|
1.0
|
|
CG
|
C:HIS161
|
4.3
|
42.5
|
1.0
|
|
CB
|
C:ALA111
|
4.3
|
65.7
|
1.0
|
|
HE1
|
C:TYR72
|
4.3
|
68.5
|
1.0
|
|
HH
|
C:TYR72
|
4.3
|
73.5
|
1.0
|
|
HD3
|
C:PRO112
|
4.4
|
73.6
|
1.0
|
|
HB3
|
C:GLN165
|
4.4
|
84.5
|
1.0
|
|
C
|
C:CYS79
|
4.5
|
54.9
|
1.0
|
|
N
|
C:CYS79
|
4.5
|
53.0
|
1.0
|
|
H
|
C:THR80
|
4.6
|
60.6
|
1.0
|
|
HB2
|
C:ALA111
|
4.6
|
78.9
|
1.0
|
|
HG
|
C:SER83
|
4.7
|
76.1
|
1.0
|
|
O
|
C:PHE78
|
4.7
|
49.8
|
1.0
|
|
CA
|
C:CYS84
|
4.7
|
60.1
|
1.0
|
|
CB
|
C:GLN165
|
4.7
|
70.4
|
1.0
|
|
HG3
|
C:GLN165
|
4.7
|
83.8
|
1.0
|
|
HD1
|
C:HIS166
|
4.8
|
51.3
|
1.0
|
|
OG
|
C:SER83
|
4.8
|
63.4
|
1.0
|
|
N
|
C:THR80
|
4.8
|
50.5
|
1.0
|
|
HD1
|
C:HIS161
|
4.9
|
57.4
|
1.0
|
|
HG3
|
C:PRO112
|
4.9
|
73.8
|
1.0
|
|
HA
|
C:CYS84
|
5.0
|
72.1
|
1.0
|
|
C
|
C:PHE78
|
5.0
|
49.5
|
1.0
|
|
Zinc binding site 4 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 4 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn301
b:39.6
occ:1.00
|
NE2
|
D:HIS161
|
2.0
|
72.1
|
1.0
|
|
NE2
|
D:HIS166
|
2.0
|
54.2
|
1.0
|
|
SG
|
D:CYS79
|
2.2
|
54.9
|
1.0
|
|
SG
|
D:CYS84
|
2.2
|
71.1
|
1.0
|
|
HB2
|
D:CYS84
|
2.8
|
95.9
|
1.0
|
|
CE1
|
D:HIS161
|
2.8
|
75.3
|
1.0
|
|
HE1
|
D:HIS161
|
2.9
|
90.3
|
1.0
|
|
CE1
|
D:HIS166
|
3.0
|
54.4
|
1.0
|
|
CB
|
D:CYS84
|
3.0
|
79.9
|
1.0
|
|
HE1
|
D:HIS166
|
3.1
|
65.2
|
1.0
|
|
CD2
|
D:HIS166
|
3.1
|
53.0
|
1.0
|
|
CD2
|
D:HIS161
|
3.2
|
69.1
|
1.0
|
|
HB2
|
D:CYS79
|
3.2
|
63.6
|
1.0
|
|
HB3
|
D:CYS84
|
3.2
|
95.9
|
1.0
|
|
CB
|
D:CYS79
|
3.2
|
53.0
|
1.0
|
|
HA
|
D:CYS79
|
3.3
|
62.7
|
1.0
|
|
HD2
|
D:HIS166
|
3.3
|
63.6
|
1.0
|
|
HD2
|
D:HIS161
|
3.5
|
82.9
|
1.0
|
|
HB3
|
D:ALA111
|
3.6
|
65.8
|
1.0
|
|
HG
|
D:SER83
|
3.7
|
74.4
|
1.0
|
|
CA
|
D:CYS79
|
3.8
|
52.2
|
1.0
|
|
HB1
|
D:ALA111
|
3.8
|
65.8
|
1.0
|
|
ND1
|
D:HIS161
|
4.0
|
72.0
|
1.0
|
|
HB3
|
D:CYS79
|
4.1
|
63.6
|
1.0
|
|
ND1
|
D:HIS166
|
4.1
|
53.1
|
1.0
|
|
CB
|
D:ALA111
|
4.1
|
54.9
|
1.0
|
|
HB2
|
D:GLN165
|
4.2
|
85.5
|
1.0
|
|
HH
|
D:TYR72
|
4.2
|
55.0
|
1.0
|
|
CG
|
D:HIS166
|
4.2
|
52.3
|
1.0
|
|
CG
|
D:HIS161
|
4.2
|
69.2
|
1.0
|
|
HD3
|
D:PRO112
|
4.2
|
66.4
|
1.0
|
|
HE1
|
D:TYR72
|
4.2
|
58.6
|
1.0
|
|
HB3
|
D:GLN165
|
4.3
|
85.5
|
1.0
|
|
CA
|
D:CYS84
|
4.4
|
73.8
|
1.0
|
|
OG
|
D:SER83
|
4.4
|
62.0
|
1.0
|
|
HB2
|
D:ALA111
|
4.5
|
65.8
|
1.0
|
|
C
|
D:CYS79
|
4.6
|
52.9
|
1.0
|
|
HG3
|
D:GLN165
|
4.6
|
88.8
|
1.0
|
|
CB
|
D:GLN165
|
4.7
|
71.2
|
1.0
|
|
H
|
D:THR80
|
4.7
|
64.1
|
1.0
|
|
N
|
D:CYS84
|
4.7
|
72.1
|
1.0
|
|
HD1
|
D:HIS161
|
4.8
|
86.4
|
1.0
|
|
HG3
|
D:PRO112
|
4.8
|
66.6
|
1.0
|
|
HA
|
D:CYS84
|
4.8
|
88.5
|
1.0
|
|
H
|
D:CYS84
|
4.9
|
86.6
|
1.0
|
|
HD1
|
D:HIS166
|
4.9
|
63.8
|
1.0
|
|
N
|
D:THR80
|
5.0
|
53.4
|
1.0
|
|
N
|
D:CYS79
|
5.0
|
51.4
|
1.0
|
|
Zinc binding site 5 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 5 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn301
b:41.1
occ:1.00
|
NE2
|
E:HIS166
|
1.9
|
41.4
|
1.0
|
|
NE2
|
E:HIS161
|
2.0
|
52.7
|
1.0
|
|
SG
|
E:CYS79
|
2.3
|
37.5
|
1.0
|
|
SG
|
E:CYS84
|
2.3
|
54.7
|
1.0
|
|
CE1
|
E:HIS166
|
2.8
|
41.5
|
1.0
|
|
CE1
|
E:HIS161
|
2.8
|
55.6
|
1.0
|
|
HE1
|
E:HIS166
|
2.9
|
49.8
|
1.0
|
|
HE1
|
E:HIS161
|
2.9
|
66.7
|
1.0
|
|
CD2
|
E:HIS166
|
3.1
|
41.2
|
1.0
|
|
CD2
|
E:HIS161
|
3.1
|
51.2
|
1.0
|
|
HB2
|
E:CYS84
|
3.2
|
77.3
|
1.0
|
|
CB
|
E:CYS84
|
3.2
|
64.4
|
1.0
|
|
HB2
|
E:CYS79
|
3.2
|
45.1
|
1.0
|
|
HB3
|
E:CYS84
|
3.3
|
77.3
|
1.0
|
|
CB
|
E:CYS79
|
3.3
|
37.6
|
1.0
|
|
HD2
|
E:HIS166
|
3.3
|
49.4
|
1.0
|
|
HA
|
E:CYS79
|
3.4
|
46.9
|
1.0
|
|
HB3
|
E:ALA111
|
3.4
|
55.6
|
1.0
|
|
HD2
|
E:HIS161
|
3.4
|
61.5
|
1.0
|
|
HB1
|
E:ALA111
|
3.7
|
55.6
|
1.0
|
|
CA
|
E:CYS79
|
3.9
|
39.0
|
1.0
|
|
HB2
|
E:GLN165
|
3.9
|
76.0
|
1.0
|
|
CB
|
E:ALA111
|
3.9
|
46.3
|
1.0
|
|
ND1
|
E:HIS166
|
3.9
|
41.4
|
1.0
|
|
ND1
|
E:HIS161
|
4.0
|
56.2
|
1.0
|
|
CG
|
E:HIS166
|
4.1
|
41.2
|
1.0
|
|
HB2
|
E:ALA111
|
4.1
|
55.6
|
1.0
|
|
HB3
|
E:CYS79
|
4.1
|
45.1
|
1.0
|
|
HG
|
E:SER83
|
4.1
|
78.3
|
1.0
|
|
HB3
|
E:GLN165
|
4.1
|
76.0
|
1.0
|
|
CG
|
E:HIS161
|
4.2
|
52.4
|
1.0
|
|
HE1
|
E:TYR72
|
4.3
|
48.4
|
1.0
|
|
HD3
|
E:PRO112
|
4.4
|
51.8
|
1.0
|
|
HG3
|
E:GLN165
|
4.4
|
81.5
|
1.0
|
|
CB
|
E:GLN165
|
4.5
|
63.3
|
1.0
|
|
HH
|
E:TYR72
|
4.5
|
53.2
|
1.0
|
|
CA
|
E:CYS84
|
4.6
|
64.0
|
1.0
|
|
HD1
|
E:HIS166
|
4.7
|
49.7
|
1.0
|
|
C
|
E:CYS79
|
4.7
|
39.9
|
1.0
|
|
HD1
|
E:HIS161
|
4.7
|
67.4
|
1.0
|
|
OG
|
E:SER83
|
4.8
|
65.2
|
1.0
|
|
H
|
E:THR80
|
4.8
|
62.8
|
1.0
|
|
HA
|
E:CYS84
|
4.9
|
76.8
|
1.0
|
|
Zinc binding site 6 out
of 6 in 5brm
Go back to
Zinc Binding Sites List in 5brm
Zinc binding site 6 out
of 6 in the Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Zn301
b:77.1
occ:1.00
|
NE2
|
F:HIS166
|
1.9
|
63.1
|
1.0
|
|
NE2
|
F:HIS161
|
2.1
|
65.2
|
1.0
|
|
SG
|
F:CYS84
|
2.3
|
74.9
|
1.0
|
|
SG
|
F:CYS79
|
2.4
|
59.4
|
1.0
|
|
CE1
|
F:HIS166
|
2.9
|
63.8
|
1.0
|
|
CD2
|
F:HIS166
|
2.9
|
61.8
|
1.0
|
|
HB2
|
F:CYS79
|
3.0
|
72.2
|
1.0
|
|
HA
|
F:CYS79
|
3.0
|
77.7
|
1.0
|
|
CE1
|
F:HIS161
|
3.0
|
68.2
|
1.0
|
|
HE1
|
F:HIS166
|
3.1
|
76.5
|
1.0
|
|
CD2
|
F:HIS161
|
3.1
|
60.8
|
1.0
|
|
CB
|
F:CYS79
|
3.1
|
60.2
|
1.0
|
|
HD2
|
F:HIS166
|
3.2
|
74.2
|
1.0
|
|
HE1
|
F:HIS161
|
3.2
|
81.8
|
1.0
|
|
HB2
|
F:CYS84
|
3.2
|
0.2
|
1.0
|
|
CB
|
F:CYS84
|
3.3
|
86.0
|
1.0
|
|
HD2
|
F:HIS161
|
3.3
|
73.0
|
1.0
|
|
HB3
|
F:ALA111
|
3.5
|
0.7
|
1.0
|
|
HB3
|
F:CYS84
|
3.5
|
0.2
|
1.0
|
|
CA
|
F:CYS79
|
3.6
|
64.8
|
1.0
|
|
ND1
|
F:HIS166
|
4.0
|
61.8
|
1.0
|
|
HB3
|
F:CYS79
|
4.0
|
72.2
|
1.0
|
|
CG
|
F:HIS166
|
4.0
|
59.5
|
1.0
|
|
HB1
|
F:ALA111
|
4.1
|
0.7
|
1.0
|
|
CB
|
F:ALA111
|
4.1
|
95.6
|
1.0
|
|
ND1
|
F:HIS161
|
4.2
|
67.0
|
1.0
|
|
CG
|
F:HIS161
|
4.2
|
60.5
|
1.0
|
|
HD3
|
F:PRO112
|
4.3
|
89.2
|
1.0
|
|
HB2
|
F:GLN165
|
4.3
|
68.3
|
1.0
|
|
HG
|
F:SER83
|
4.3
|
79.5
|
1.0
|
|
HB2
|
F:ALA111
|
4.3
|
0.7
|
1.0
|
|
OG
|
F:SER83
|
4.5
|
66.2
|
1.0
|
|
C
|
F:CYS79
|
4.5
|
69.5
|
1.0
|
|
H
|
F:THR80
|
4.5
|
96.7
|
1.0
|
|
HB3
|
F:GLN165
|
4.7
|
68.3
|
1.0
|
|
HE1
|
F:TYR72
|
4.7
|
79.6
|
1.0
|
|
N
|
F:CYS79
|
4.7
|
65.9
|
1.0
|
|
HH
|
F:TYR72
|
4.7
|
92.6
|
1.0
|
|
CA
|
F:CYS84
|
4.7
|
90.7
|
1.0
|
|
HD1
|
F:HIS166
|
4.8
|
74.2
|
1.0
|
|
O
|
F:PHE78
|
4.8
|
83.3
|
1.0
|
|
N
|
F:THR80
|
4.8
|
80.6
|
1.0
|
|
CB
|
F:GLN165
|
4.9
|
57.0
|
1.0
|
|
HD1
|
F:HIS161
|
4.9
|
80.4
|
1.0
|
|
HG3
|
F:PRO112
|
5.0
|
82.5
|
1.0
|
|
Reference:
L.Ni,
Y.Zheng,
M.Hara,
D.Pan,
X.Luo.
Structural Basis For MOB1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling. Genes Dev. V. 29 1416 2015.
ISSN: ISSN 0890-9369
PubMed: 26108669
DOI: 10.1101/GAD.264929.115
Page generated: Sun Oct 27 13:33:42 2024
|
