Zinc in PDB 4tpj: Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2

The structure of Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2, PDB code: 4tpj was solved by F.Guettou, E.Quistgaard, M.Raba, P.Moberg, C.Low, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.56 / 3.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.990, 107.560, 203.710, 90.00, 90.00, 90.00
R / Rfree (%)	24.4 / 29

The binding sites of Zinc atom in the Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2 (pdb code 4tpj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2, PDB code: 4tpj:

Zinc binding site 1 out of 1 in the Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Selectivity Mechanism of A Bacterial Homologue of the Human Drug Peptide Transporters PEPT1 and PEPT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:0.0 occ:1.00 OD1 B:ASN468 2.8 98.2 1.0 CG B:ASN468 3.7 73.1 1.0 CB B:ASN468 3.9 57.8 1.0 OD1 A:ASN468 3.9 60.4 1.0 CG A:ASN468 4.1 56.5 1.0 CE2 A:PHE372 4.3 59.8 1.0 CE2 B:PHE372 4.4 55.5 1.0 CD2 A:PHE372 4.5 61.8 1.0 ND2 A:ASN468 4.6 58.0 1.0 CB A:ASN468 4.6 53.9 1.0 O B:ASN468 4.7 63.8 1.0 CG2 B:VAL472 4.7 60.3 1.0 CA B:ASN468 4.8 55.4 1.0 CD2 B:PHE372 4.8 79.7 1.0 ND2 B:ASN468 4.9 68.5 1.0

F.Guettou, E.M.Quistgaard, M.Raba, P.Moberg, C.Low, P.Nordlund. Selectivity Mechanism of A Bacterial Homolog of the Human Drug-Peptide Transporters PEPT1 and PEPT2. Nat.Struct.Mol.Biol. V. 21 728 2014.
ISSN: ESSN 1545-9985
PubMed: 25064511
DOI: 10.1038/NSMB.2860