Atomistry » Zinc » PDB 3t5w-3te7 » 3t6p
Atomistry »
  Zinc »
    PDB 3t5w-3te7 »
      3t6p »

Zinc in PDB 3t6p: Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization

Protein crystallography data

The structure of Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization, PDB code: 3t6p was solved by E.C.Dueber, A.J.Schoeffler, A.Lingel, M.Elliott, A.V.Fedorova, A.M.Giannetti, K.Zobel, B.Maurer, E.Varfolomeev, P.Wu, H.Wallweber, S.Hymowitz, K.Deshayes, D.Vucic, W.J.Fairbrother, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.78 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 37.971, 85.432, 106.484, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 23.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization (pdb code 3t6p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization, PDB code: 3t6p:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 3t6p

Go back to Zinc Binding Sites List in 3t6p
Zinc binding site 1 out of 3 in the Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:31.5
occ:1.00
SG A:CYS571 2.4 26.3 1.0
SG A:CYS592 2.4 29.2 1.0
SG A:CYS595 2.4 34.2 1.0
SG A:CYS574 2.4 33.6 1.0
CB A:CYS571 3.1 24.2 1.0
CB A:CYS595 3.1 32.2 1.0
CB A:CYS574 3.2 42.6 1.0
CB A:CYS592 3.6 26.9 1.0
N A:CYS574 3.6 27.3 1.0
N A:CYS592 4.0 30.6 1.0
CA A:CYS574 4.0 37.9 1.0
O A:HOH195 4.1 53.7 1.0
N A:CYS595 4.2 35.9 1.0
CA A:CYS595 4.3 29.8 1.0
CA A:CYS592 4.3 29.2 1.0
CA A:CYS571 4.6 23.3 1.0
CB A:VAL573 4.6 36.6 1.0
C A:VAL573 4.7 39.5 1.0
C A:CYS592 4.8 34.6 1.0
O A:CYS592 4.8 26.2 1.0
CB A:LYS577 4.9 33.7 1.0
C A:CYS574 4.9 36.7 1.0
C A:CYS571 5.0 27.4 1.0

Zinc binding site 2 out of 3 in 3t6p

Go back to Zinc Binding Sites List in 3t6p
Zinc binding site 2 out of 3 in the Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1002

b:25.2
occ:1.00
NE2 A:HIS326 2.2 27.2 1.0
SG A:CYS306 2.3 23.8 1.0
SG A:CYS333 2.3 24.0 1.0
SG A:CYS309 2.4 25.9 1.0
CE1 A:HIS326 2.8 35.1 1.0
CB A:CYS333 3.1 25.2 1.0
CB A:CYS306 3.1 25.3 1.0
CB A:CYS309 3.2 29.1 1.0
CD2 A:HIS326 3.4 29.3 1.0
N A:CYS309 3.6 29.0 1.0
CA A:CYS309 4.0 33.0 1.0
ND1 A:HIS326 4.1 28.4 1.0
CG A:HIS326 4.3 27.8 1.0
CB A:SER308 4.4 27.7 1.0
CA A:CYS333 4.5 26.6 1.0
CA A:CYS306 4.6 27.1 1.0
C A:SER308 4.7 36.6 1.0
CB A:PHE330 4.8 23.4 1.0
C A:CYS309 4.8 31.0 1.0
N A:SER308 4.9 29.0 1.0
CA A:SER308 4.9 35.4 1.0
N A:ASP310 5.0 36.3 1.0

Zinc binding site 3 out of 3 in 3t6p

Go back to Zinc Binding Sites List in 3t6p
Zinc binding site 3 out of 3 in the Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Iap Antagonist-Induced Conformational Change in CIAP1 Promotes E3 Ligase Activation Via Dimerization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1003

b:30.9
occ:1.00
ND1 A:HIS588 2.1 31.7 1.0
SG A:CYS602 2.1 28.7 1.0
SG A:CYS586 2.4 31.7 1.0
SG A:CYS605 2.4 35.6 1.0
CB A:CYS602 3.0 23.5 1.0
CE1 A:HIS588 3.1 41.4 1.0
CG A:HIS588 3.2 27.9 1.0
CB A:CYS586 3.2 33.8 1.0
CB A:HIS588 3.5 27.1 1.0
CB A:CYS605 3.5 41.5 1.0
N A:CYS605 3.9 36.5 1.0
NE2 A:HIS588 4.2 36.9 1.0
CD2 A:HIS588 4.2 36.5 1.0
CA A:CYS605 4.3 34.8 1.0
CA A:CYS602 4.4 27.9 1.0
CB A:ILE604 4.5 35.1 1.0
CA A:CYS586 4.6 37.8 1.0
N A:HIS588 4.6 28.0 1.0
CA A:HIS588 4.7 27.4 1.0
CD2 A:PHE583 4.7 28.6 1.0
C A:CYS586 4.8 36.6 1.0
C A:ILE604 4.9 43.1 1.0
O A:CYS586 4.9 33.7 1.0
C A:CYS602 5.0 35.8 1.0
C A:CYS605 5.0 32.2 1.0

Reference:

E.C.Dueber, A.J.Schoeffler, A.Lingel, J.M.Elliott, A.V.Fedorova, A.M.Giannetti, K.Zobel, B.Maurer, E.Varfolomeev, P.Wu, H.J.Wallweber, S.G.Hymowitz, K.Deshayes, D.Vucic, W.J.Fairbrother. Antagonists Induce A Conformational Change in CIAP1 That Promotes Autoubiquitination. Science V. 334 376 2011.
ISSN: ISSN 0036-8075
PubMed: 22021857
DOI: 10.1126/SCIENCE.1207862
Page generated: Wed Dec 16 04:51:32 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy