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Atomistry » Zinc » PDB 3kr7-3l2q » 3kr8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 3kr7-3l2q » 3kr8 » |
Zinc in PDB 3kr8: Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939Enzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939
All present enzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939:
2.4.2.30; Protein crystallography data
The structure of Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939, PDB code: 3kr8
was solved by
T.Karlberg,
P.Schutz,
C.H.Arrowsmith,
H.Berglund,
C.Bountra,
R.Collins,
A.M.Edwards,
S.Flodin,
A.Flores,
S.Graslund,
M.Hammarstrom,
A.Johansson,
I.Johansson,
A.Kallas,
T.Kotenyova,
A.Kotzsch,
P.Kraulis,
T.K.Nielsen,
M.Moche,
P.Nordlund,
T.Nyman,
C.Persson,
M.I.Siponen,
A.G.Thorsell,
L.Tresaugues,
S.Van Den Berg,
J.Weigelt,
M.Welin,
M.Wisniewska,
H.Schuler,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3kr8:
The structure of Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939
(pdb code 3kr8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939, PDB code: 3kr8: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 3kr8Go back to Zinc Binding Sites List in 3kr8
Zinc binding site 1 out
of 2 in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 3kr8Go back to Zinc Binding Sites List in 3kr8
Zinc binding site 2 out
of 2 in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with An Inhibitor XAV939
Mono view Stereo pair view
Reference:
T.Karlberg,
N.Markova,
I.Johansson,
M.Hammarstrom,
P.Schutz,
J.Weigelt,
H.Schuler.
Structural Basis For the Interaction Between Tankyrase-2 and A Potent Wnt-Signaling Inhibitor. J.Med.Chem. V. 53 5352 2010.
Page generated: Wed Dec 16 04:30:59 2020
ISSN: ISSN 0022-2623 PubMed: 20565110 DOI: 10.1021/JM100249W |
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