Zinc in PDB 3fuk: Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid

Enzymatic activity of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid

All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid:
3.3.2.6;

Protein crystallography data

The structure of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid, PDB code: 3fuk was solved by D.R.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.95
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.176, 87.220, 99.899, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 23.3

Other elements in 3fuk:

The structure of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid also contains other interesting chemical elements:

Ytterbium (Yb) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid (pdb code 3fuk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid, PDB code: 3fuk:

Zinc binding site 1 out of 1 in 3fuk

Go back to Zinc Binding Sites List in 3fuk
Zinc binding site 1 out of 1 in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:22.1
occ:1.00
 OE1 A:GLU318 2.0 23.0 1.0
O20 A:58Z710 2.0 33.9 1.0
NE2 A:HIS295 2.1 15.9 1.0
NE2 A:HIS299 2.1 17.1 1.0
O21 A:58Z710 2.7 34.3 1.0
C19 A:58Z710 2.7 39.7 1.0
CD A:GLU318 2.8 18.8 1.0
OE2 A:GLU318 2.8 18.3 1.0
CD2 A:HIS295 3.0 14.7 1.0
CE1 A:HIS299 3.0 16.8 1.0
CE1 A:HIS295 3.1 17.1 1.0
CD2 A:HIS299 3.1 16.3 1.0
O A:HOH864 3.7 28.3 1.0
CE2 A:TYR383 3.8 18.8 1.0
OH A:TYR383 4.1 19.9 1.0
ND1 A:HIS299 4.2 14.7 1.0
ND1 A:HIS295 4.2 15.4 1.0
CG A:HIS295 4.2 17.0 1.0
C16 A:58Z710 4.2 43.1 1.0
CG A:HIS299 4.2 14.3 1.0
CG A:GLU318 4.2 16.4 1.0
CZ A:TYR383 4.3 20.3 1.0
CG2 A:THR321 4.3 17.7 1.0
OE2 A:GLU271 4.4 16.1 1.0
CD2 A:TYR383 4.7 18.7 1.0
O A:HOH663 4.7 18.7 1.0
CB A:THR321 4.7 16.4 1.0
CB A:GLU318 4.8 16.7 1.0
OE1 A:GLU271 4.8 18.6 1.0
OE2 A:GLU296 4.8 22.8 1.0
C15 A:58Z710 4.9 46.1 1.0
CA A:GLU318 4.9 16.6 1.0
CD A:GLU271 4.9 17.8 1.0

Reference:

D.R.Davies, B.Mamat, O.T.Magnusson, J.Christensen, M.H.Haraldsson, R.Mishra, B.Pease, E.Hansen, J.Singh, D.Zembower, H.Kim, A.S.Kiselyov, A.B.Burgin, M.E.Gurney, L.J.Stewart. Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
Page generated: Thu Oct 24 13:26:18 2024

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