Zinc in PDB 2v1x: Crystal Structure of Human Recq-Like Dna Helicase

The structure of Crystal Structure of Human Recq-Like Dna Helicase, PDB code: 2v1x was solved by A.C.W.Pike, B.Shrestha, N.Burgess-Brown, O.King, E.Ugochukwu, S.Watt, A.Edwards, C.H.Arrowsmith, J.Weigelt, M.Sundstrom, O.Gileadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.00 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	83.229, 97.647, 85.849, 90.00, 104.50, 90.00
R / Rfree (%)	23.2 / 27.8

The structure of Crystal Structure of Human Recq-Like Dna Helicase also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Chlorine	(Cl)	9 atoms

The binding sites of Zinc atom in the Crystal Structure of Human Recq-Like Dna Helicase (pdb code 2v1x). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Recq-Like Dna Helicase, PDB code: 2v1x:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Recq-Like Dna Helicase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Recq-Like Dna Helicase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1595 b:43.2 occ:1.00 SG A:CYS475 2.3 36.5 1.0 SG A:CYS478 2.3 50.3 1.0 SG A:CYS453 2.3 42.4 1.0 SG A:CYS471 2.4 44.2 1.0 CB A:CYS478 3.2 45.1 1.0 CB A:CYS471 3.3 48.7 1.0 CB A:CYS475 3.4 29.2 1.0 CB A:CYS453 3.5 40.1 1.0 CA A:CYS453 3.8 38.8 1.0 N A:ARG454 3.9 33.5 1.0 N A:CYS475 4.1 33.6 1.0 C A:CYS453 4.3 36.4 1.0 CA A:CYS475 4.3 33.4 1.0 N A:CYS478 4.3 47.3 1.0 CA A:CYS478 4.3 47.2 1.0 C A:MET474 4.7 36.4 1.0 N A:ARG455 4.7 37.2 1.0 CA A:CYS471 4.7 48.4 1.0 O A:CYS475 4.7 38.7 1.0 N A:MET474 4.8 37.5 1.0 C A:CYS475 4.8 35.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Recq-Like Dna Helicase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Recq-Like Dna Helicase within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1595 b:43.4 occ:1.00 SG B:CYS475 2.3 33.9 1.0 SG B:CYS453 2.3 38.7 1.0 SG B:CYS478 2.3 40.4 1.0 SG B:CYS471 2.4 39.4 1.0 CB B:CYS475 3.3 25.8 1.0 CB B:CYS471 3.3 48.5 1.0 CB B:CYS478 3.3 45.2 1.0 CB B:CYS453 3.4 39.0 1.0 CA B:CYS453 3.8 37.6 1.0 N B:CYS475 4.0 34.5 1.0 N B:ARG454 4.0 32.9 1.0 CA B:CYS475 4.2 34.7 1.0 C B:CYS453 4.3 36.7 1.0 N B:CYS478 4.3 45.9 1.0 CA B:CYS478 4.4 47.4 1.0 C B:MET474 4.6 36.3 1.0 N B:ARG455 4.7 36.4 1.0 CA B:CYS471 4.7 46.5 1.0 N B:MET474 4.7 37.7 1.0 O B:CYS475 4.7 33.5 1.0 C B:CYS475 4.8 35.2 1.0 O B:HOH2123 4.8 48.0 1.0

A.C.W.Pike, B.Shrestha, V.Popuri, N.Burgess-Brown, L.Muzzolini, S.Costantini, A.Vindigni, O.Gileadi. Structure of the Human RECQ1 Helicase Reveals A Putative Strand-Separation Pin. Proc.Natl.Acad.Sci.Usa V. 106 1039 2009.
ISSN: ISSN 0027-8424
PubMed: 19151156
DOI: 10.1073/PNAS.0806908106