Zinc in PDB 2pcu: Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide.

The structure of Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide., PDB code: 2pcu was solved by A.Bayes, D.Fernandez, M.Sola, A.Marrero, S.Garcia-Pique, F.X.Aviles, J.Vendrell, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.304, 72.494, 81.575, 90.00, 90.00, 90.00
R / Rfree (%)	15.9 / 17.6

The binding sites of Zinc atom in the Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide. (pdb code 2pcu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide., PDB code: 2pcu:

Zinc binding site 1 out of 1 in the Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carboxypeptidase A4 in Complex with A Cleaved Hexapeptide. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn999 b:25.4 occ:1.00 ND1 A:HIS69 2.1 20.8 1.0 ND1 A:HIS196 2.1 23.2 1.0 OE2 A:GLU72 2.2 22.7 1.0 OXT B:VAL5 2.2 16.0 1.0 O B:VAL5 2.3 16.2 1.0 C B:VAL5 2.6 17.9 1.0 OE1 A:GLU72 2.6 23.2 1.0 CD A:GLU72 2.7 20.7 1.0 CE1 A:HIS69 3.0 20.5 1.0 CE1 A:HIS196 3.0 23.8 1.0 CG A:HIS69 3.2 19.4 1.0 CG A:HIS196 3.2 21.9 1.0 CB A:HIS196 3.6 22.6 1.0 CB A:HIS69 3.6 19.0 1.0 CA B:VAL5 4.1 16.1 1.0 NH2 A:ARG127 4.1 23.7 1.0 NE2 A:HIS69 4.1 21.3 1.0 NE2 A:HIS196 4.1 23.6 1.0 O A:HOH581 4.2 18.1 1.0 O A:HOH589 4.2 14.8 1.0 CG A:GLU72 4.2 20.5 1.0 CD2 A:HIS69 4.2 20.7 1.0 CD2 A:HIS196 4.3 21.8 1.0 O A:SER197 4.3 23.1 1.0 OXT B:ASP6 4.3 28.4 0.5 CB B:ASP6 4.3 23.2 1.0 OD1 B:ASP6 4.3 13.3 1.0 CG B:ASP6 4.4 18.2 1.0 CA A:HIS196 4.5 21.4 1.0 OE2 A:GLU270 4.7 35.0 1.0 N A:SER197 4.8 22.5 1.0 OE1 A:GLU270 4.9 29.9 1.0 CZ A:ARG127 4.9 23.5 1.0 OD2 B:ASP6 4.9 14.6 1.0 N B:VAL5 4.9 16.7 1.0 CA A:HIS69 5.0 21.4 1.0

A.Bayes, D.Fernandez, M.Sola, A.Marrero, S.Garcia-Pique, F.X.Aviles, J.Vendrell, F.X.Gomis-Ruth. Caught After the Act: A Human A-Type Metallocarboxypeptidase in A Product Complex with A Cleaved Hexapeptide. Biochemistry V. 46 6921 2007.
ISSN: ISSN 0006-2960
PubMed: 17506531
DOI: 10.1021/BI700480B