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Zinc in PDB 1xuj: Trypsin-Keto-Babim-Zn+2, pH 8.2

Enzymatic activity of Trypsin-Keto-Babim-Zn+2, pH 8.2

All present enzymatic activity of Trypsin-Keto-Babim-Zn+2, pH 8.2:
3.4.21.4;

Protein crystallography data

The structure of Trypsin-Keto-Babim-Zn+2, pH 8.2, PDB code: 1xuj was solved by B.A.Katz, J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Rose, C.Luong, W.R.Moore, R.M.Stroud, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.92
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 55.060, 55.060, 109.850, 90.00, 90.00, 120.00
R / Rfree (%) 14.4 / 17.1

Other elements in 1xuj:

The structure of Trypsin-Keto-Babim-Zn+2, pH 8.2 also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Trypsin-Keto-Babim-Zn+2, pH 8.2 (pdb code 1xuj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trypsin-Keto-Babim-Zn+2, pH 8.2, PDB code: 1xuj:

Zinc binding site 1 out of 1 in 1xuj

Go back to Zinc Binding Sites List in 1xuj
Zinc binding site 1 out of 1 in the Trypsin-Keto-Babim-Zn+2, pH 8.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trypsin-Keto-Babim-Zn+2, pH 8.2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn246

b:8.5
occ:1.00
ZN A:BOZ246 0.0 8.5 1.0
OG A:SER195 1.9 6.7 1.0
N3' A:BOZ246 1.9 15.9 1.0
N3 A:BOZ246 2.0 12.0 1.0
NE2 A:HIS57 2.2 9.4 1.0
CB A:SER195 2.8 6.3 1.0
C8' A:BOZ246 2.9 17.4 1.0
C4' A:BOZ246 3.0 16.1 1.0
C8 A:BOZ246 3.0 15.6 1.0
C4 A:BOZ246 3.1 14.2 1.0
CD2 A:HIS57 3.1 9.6 1.0
CE1 A:HIS57 3.1 10.7 1.0
C9 A:BOZ246 3.3 17.5 1.0
C3' A:BOZ246 3.4 15.2 1.0
C3 A:BOZ246 3.6 9.6 1.0
O A:HOH328 3.8 28.0 1.0
CA A:SER195 3.9 9.7 1.0
O A:HOH337 3.9 18.1 1.0
N4' A:BOZ246 4.1 18.4 1.0
O A:SER214 4.1 4.6 1.0
H A:SER195 4.1 0.0 1.0
C5' A:BOZ246 4.1 17.7 1.0
H A:GLY193 4.1 0.0 1.0
N4 A:BOZ246 4.2 14.7 1.0
ND1 A:HIS57 4.2 10.0 1.0
C5 A:BOZ246 4.2 14.0 1.0
CG A:HIS57 4.3 8.7 1.0
H2 A:HOH328 4.3 0.0 1.0
H1 A:HOH328 4.3 0.0 1.0
H1 A:HOH337 4.4 0.0 1.0
H2 A:HOH337 4.4 0.0 1.0
N A:SER195 4.5 7.8 1.0
O9 A:BOZ246 4.5 17.2 1.0
CA A:GLN192 4.6 15.7 1.0
H2 A:HOH332 4.7 0.0 1.0
CG A:GLN192 4.8 20.6 0.5
CB A:GLN192 4.8 18.2 0.4
C2' A:BOZ246 4.9 17.3 1.0
CB A:GLN192 4.9 16.8 0.5
HN4' A:BOZ246 4.9 0.0 1.0
HN4 A:BOZ246 5.0 0.0 1.0

Reference:

B.A.Katz, J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross, C.Luong, W.R.Moore, R.M.Stroud. Design of Potent Selective Zinc-Mediated Serine Protease Inhibitors. Nature V. 391 608 1998.
ISSN: ISSN 0028-0836
PubMed: 9468142
DOI: 10.1038/35422
Page generated: Wed Dec 16 03:13:18 2020

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