Atomistry » Zinc » PDB 1m2k-1mkd » 1m2n
Atomistry »
  Zinc »
    PDB 1m2k-1mkd »
      1m2n »

Zinc in PDB 1m2n: SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex

Protein crystallography data

The structure of SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex, PDB code: 1m2n was solved by J.Chang, Y.Cho, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.91 / 2.60
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 84.720, 84.720, 193.087, 90.00, 90.00, 120.00
R / Rfree (%) 22.8 / 30.8

Zinc Binding Sites:

The binding sites of Zinc atom in the SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex (pdb code 1m2n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex, PDB code: 1m2n:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 1m2n

Go back to Zinc Binding Sites List in 1m2n
Zinc binding site 1 out of 2 in the SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn999

b:86.0
occ:1.00
SG A:CYS127 2.3 84.0 1.0
SG A:CYS124 2.3 84.7 1.0
SG A:CYS148 2.3 85.4 1.0
SG A:CYS145 2.3 84.3 1.0
CB A:CYS124 3.1 79.8 1.0
CB A:CYS127 3.2 83.1 1.0
N A:CYS148 3.5 85.2 1.0
CB A:CYS148 3.6 84.8 1.0
N A:CYS127 3.7 78.9 1.0
CB A:CYS145 3.7 85.6 1.0
CA A:CYS127 4.0 81.2 1.0
CB A:LYS147 4.0 85.2 1.0
CA A:CYS148 4.0 85.1 1.0
N A:GLY149 4.2 83.2 1.0
N A:SER150 4.3 80.8 1.0
C A:CYS148 4.4 84.5 1.0
CB A:SER150 4.5 80.4 1.0
CB A:ASN129 4.5 74.7 1.0
C A:LYS147 4.6 85.1 1.0
CA A:CYS124 4.6 76.5 1.0
C A:CYS127 4.6 81.9 1.0
CA A:LYS147 4.7 85.3 1.0
C A:SER126 4.8 77.2 1.0
O A:SER150 4.8 78.5 1.0
O A:CYS127 4.8 82.8 1.0
N A:SER126 4.9 73.3 1.0
ND2 A:ASN129 4.9 71.4 1.0
CB A:SER126 4.9 76.1 1.0
CA A:SER150 4.9 79.7 1.0
OG A:SER150 4.9 80.9 1.0
N A:LYS147 4.9 85.8 1.0
CA A:CYS145 5.0 86.5 1.0

Zinc binding site 2 out of 2 in 1m2n

Go back to Zinc Binding Sites List in 1m2n
Zinc binding site 2 out of 2 in the SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of SIR2 Homologues (D102G/F159A/R170A) Mutant-2'-O-Acetyl Adp Ribose Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn999

b:93.5
occ:1.00
SG B:CYS127 2.3 91.7 1.0
SG B:CYS145 2.3 92.0 1.0
SG B:CYS124 2.3 92.4 1.0
SG B:CYS148 2.3 94.3 1.0
CB B:CYS127 3.1 90.7 1.0
CB B:CYS145 3.2 91.6 1.0
CB B:CYS124 3.3 87.9 1.0
N B:CYS127 3.4 88.7 1.0
OG B:SER150 3.5 87.5 1.0
CB B:CYS148 3.7 95.0 1.0
CA B:CYS127 3.8 89.3 1.0
N B:CYS148 4.1 95.5 1.0
CA B:CYS148 4.4 95.1 1.0
CB B:SER126 4.5 88.6 1.0
CB B:ASN129 4.5 85.4 1.0
C B:CYS127 4.5 89.0 1.0
C B:SER126 4.6 88.9 1.0
N B:GLY149 4.6 94.2 1.0
CA B:CYS145 4.7 91.3 1.0
CB B:LYS147 4.7 94.2 1.0
CA B:CYS124 4.7 84.2 1.0
C B:CYS148 4.8 94.7 1.0
CA B:SER126 4.9 89.0 1.0
CB B:SER150 4.9 87.6 1.0
N B:ASN128 4.9 88.5 1.0
N B:SER126 4.9 88.6 1.0
N B:ASN129 4.9 87.0 1.0

Reference:

J.H.Chang, H.C.Kim, K.Y.Hwang, J.W.Lee, S.P.Jackson, S.D.Bell, Y.Cho. Structural Basis For the Nad-Dependent Deacetylase Mechanism of SIR2 J.Biol.Chem. V. 277 34489 2003.
ISSN: ISSN 0021-9258
PubMed: 12091395
DOI: 10.1074/JBC.M205460200
Page generated: Mon Jan 25 16:10:06 2021

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy